The TP53 Database

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Important Notice: Website Address Update

We are pleased to inform you that to improve consistency with current guidelines from the National Cancer Institute/NIH, our website address has been updated on August 7th, 2024:

Old Address: https://tp53.isb-cgc.org

Updated Address: https://tp53.cancer.gov

You have been automatically redirected to our new address. Please update your bookmarks accordingly. The redirection service will be available until August 31st, 2024. Thank you for your understanding and continued support. The TP53 database team.

Functional / Structural Data

Search by Gene Variants Search by Variant Features View Validated Polymorphisms Downloads

Explore functional and structural data and frequency statistics of all possible single nucleotide substitutions in TP53 exonic sequences, other variants reported in human samples, and validated polymorphisms.

Tumor Variants

Search Tumor Variant Data Search Variant Prevalence Data Selected Statistics Downloads

Explore data for TP53 tumor variants identified in human tumor samples. Includes data on the type and position of variants, detailed information on the tumor in which the variants have been found, and on various characteristics of the patients in which the tumor developed.

Germline Variants

Search Germline Variant Data Selected Statistics Downloads

Explore data for individuals that are carriers of a TP53 germline variant and families in which at least one family member has been identified as a carrier of a germline variant in the TP53 gene.

Cell Lines

Search Cell-Line Data Selected Statistics Downloads

Explore data for cell-lines that have been screened for TP53 variant and have been published in the scientific literature, in the Sanger cell-line database, or the Broad Cancer cell-line Encyclopedia.

Mouse Models

View Data Downloads

Explore data for mouse models with engineered p53 that are compiled in the caMOD database or reported in the scientific literature.

Experimentally Induced Variants

View Data Downloads

Explore data for variants in the human TP53 gene obtained from mutagenicity assays in the Hupki mouse model (MEF cells treated with the indicated carcinogen agent) or in a yeast assay.