TP53 Database: Search Tumor Variants

Reference

Author	Year	Title	Journal	PubMed	Abstract
Harlow E;Williamson NM;Ralston R;Helfman DM;Adams TE;	1985	Molecular cloning and in vitro expression of a cDNA clone for human cellular tumor antigen p53	Mol Cell Biol	3894933
Wolf D;Rotter V;	1985	Major deletions in the gene encoding the p53 tumor antigen cause lack of p53 expression in HL-60 cells	Proc Natl Acad Sci U S A	2858093
Harris N;Brill E;Shohat O;Prokocimer M;Wolf D;Arai N;Rotter V;	1986	Molecular basis for heterogeneity of the human p53 protein	Mol Cell Biol	3025664
Nigro JM;Baker SJ;Preisinger AC;Jessup JM;Hostetter R;Cleary K;Bigner SH;Davidson N;Baylin S;Devilee P;	1989	Mutations in the p53 gene occur in diverse human tumour types	Nature	0002531845
Baker SJ;Fearon ER;Nigro JM;Hamilton SR;Preisinger AC;Jessup JM;van Tuinen P;Ledbetter DH;Barker DF;Nakamura Y;	1989	Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas	Science	0002649981
Takahashi T;Nau MM;Chiba I;Birrer MJ;Rosenberg RK;Vinocour M;Levitt M;Pass H;Gazdar AF;Minna JD;	1989	p53: a frequent target for genetic abnormalities in lung cancer	Science	0002554494
Romano JW;Ehrhart JC;Duthu A;Kim CM;Appella E;May P;	1989	Identification and characterization of a p53 gene mutation in a human osteosarcoma cell line	Oncogene	0002531855
Iggo R;Gatter K;Bartek J;Lane D;Harris AL;	1990	Increased expression of mutant forms of p53 oncogene in primary lung cancer	Lancet	0001969059
Bartek J;Iggo R;Gannon J;Lane DP;	1990	Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines	Oncogene	0001694291
Chiba I;Takahashi T;Nau MM;D'Amico D;Curiel DT;Mitsudomi T;Buchhagen DL;Carbone D;Piantadosi S;Koga H;	1990	Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer. Lung Cancer Study Group	Oncogene	0001979160
Stratton MR;Moss S;Warren W;Patterson H;Clark J;Fisher C;Fletcher CD;Ball A;Thomas M;Gusterson BA;	1990	Mutation of the p53 gene in human soft tissue sarcomas: association with abnormalities of the RB1 gene	Oncogene	0002216456
Baker SJ;Preisinger AC;Jessup JM;Paraskeva C;Markowitz S;Willson JK;Hamilton S;Vogelstein B;	1990	p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis	Cancer Res	0002253215
Foti A;Bar-Eli M;Ahuja HG;Cline MJ;	1990	A splicing mutation accounts for the lack of p53 gene expression in a CML blast crisis cell line: a novel mechanism of p53 gene inactivation	Br J Haematol	0002223633
Takahashi T;D'Amico D;Chiba I;Buchhagen DL;Minna JD;	1990	Identification of intronic point mutations as an alternative mechanism for p53 inactivation in lung cancer	J Clin Invest	0002164047
Cheng J;Haas M;	1990	Frequent mutations in the p53 tumor suppressor gene in human leukemia T- cell lines	Mol Cell Biol	0002144611
Diller L;Kassel J;Nelson CE;Gryka MA;Litwak G;Gebhardt M;Bressac B;Ozturk M;Baker SJ;Vogelstein B;etal.	1990	p53 functions as a cell cycle control protein in osteosarcomas	Mol Cell Biol	2233717
Rodrigues NR;Rowan A;Smith ME;Kerr IB;Bodmer WF;Gannon JV;Lane DP;	1990	p53 mutations in colorectal cancer	Proc Natl Acad Sci U S A	0001699228
Mulligan LM;Matlashewski GJ;Scrable HJ;Cavenee WK;	1990	Mechanisms of p53 loss in human sarcomas	Proc Natl Acad Sci U S A	0002143022
Menon AG;Anderson KM;Riccardi VM;Chung RY;Whaley JM;Yandell DW;Farmer GE;Freiman RN;Lee JK;Li FP;	1990	Chromosome 17p deletions and p53 gene mutations associated with the formation of malignant neurofibrosarcomas in von Recklinghausen neurofibromatosis	Proc Natl Acad Sci U S A	0002142531
Hollstein MC;Metcalf RA;Welsh JA;Montesano R;Harris CC;	1990	Frequent mutation of the p53 gene in human esophageal cancer	Proc Natl Acad Sci U S A	0002263646
Bressac B;Galvin KM;Liang TJ;Isselbacher KJ;Wands JR;Ozturk M;	1990	Abnormal structure and expression of p53 gene in human hepatocellular carcinoma	Proc Natl Acad Sci U S A	2155427
Slingerland JM;Minden MD;Benchimol S;	1991	Mutation of the p53 gene in human acute myelogenous leukemia	Blood	0002009369
Foti A;Ahuja HG;Allen SL;Koduru P;Schuster MW;Schulman P;Bar-Eli M;Cline MJ;	1991	Correlation between molecular and clinical events in the evolution of chronic myelocytic leukemia to blast crisis	Blood	0002039825
Sugimoto K;Toyoshima H;Sakai R;Miyagawa K;Hagiwara K;Hirai H;Ishikawa F;Takaku F;	1991	Mutations of the p53 gene in lymphoid leukemia	Blood	0001705829
Fenaux P;Jonveaux P;Quiquandon I;Lai JL;Pignon JM;Loucheux-Lefebvre MH;Bauters F;Berger R;Kerckaert JP;	1991	P53 gene mutations in acute myeloid leukemia with 17p monosomy	Blood	0001912553
Farrell PJ;Allan GJ;Shanahan F;Vousden KH;Crook T;	1991	p53 is frequently mutated in Burkitt's lymphoma cell lines	EMBO J	0001915267
Bressac B;Kew M;Wands J;Ozturk M;	1991	Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa	Nature	0001672732
Hsu IC;Metcalf RA;Sun T;Welsh JA;Wang NJ;Harris CC;	1991	Mutational hotspot in the p53 gene in human hepatocellular carcinomas	Nature	0001849234
Sidransky D;Von Eschenbach A;Tsai YC;Jones P;Summerhayes I;Marshall F;Paul M;Green P;Hamilton SR;Frost P;	1991	Identification of p53 gene mutations in bladder cancers and urine samples	Science	0002024123
Soudon J;Caron dF;Bernard O;Larsen CJ;	1991	Inactivation of the p53 gene expression by a splice donor site mutation in a human T-cell leukemia cell line	Leukemia	0001961027
Mashiyama S;Murakami Y;Yoshimoto T;Sekiya T;Hayashi K;	1991	Detection of p53 gene mutations in human brain tumors by single-strand conformation polymorphism analysis of polymerase chain reaction products	Oncogene	0001886708
Mazars R;Pujol P;Maudelonde T;Jeanteur P;Theillet C;	1991	p53 mutations in ovarian cancer: a late event?	Oncogene	0001923532
Bennett WP;Hollstein MC;He A;Zhu SM;Resau JH;Trump BF;Metcalf RA;Welsh JA;Midgley C;Lane DP;	1991	Archival analysis of p53 genetic and protein alterations in Chinese esophageal cancer	Oncogene	0001923503
Varley JM;Brammar WJ;Lane DP;Swallow JE;Dolan C;Walker RA;	1991	Loss of chromosome 17p13 sequences and mutation of p53 in human breast carcinomas	Oncogene	0002011397
Hensel CH;Xiang RH;Sakaguchi AY;Naylor SL;	1991	Use of the single strand conformation polymorphism technique and PCR to detect p53 gene mutations in small cell lung cancer	Oncogene	0001648702
Crook T;Wrede D;Tidy J;Scholefield J;Crawford L;Vousden KH;	1991	Status of c-myc, p53 and retinoblastoma genes in human papillomavirus positive and negative squamous cell carcinomas of the anus	Oncogene	0001650445
Wright PA;Lemoine NR;Goretzki PE;Wyllie FS;Bond J;Hughes C;Roher HD;Williams ED;Wynford-Thomas D;	1991	Mutation of the p53 gene in a differentiated human thyroid carcinoma cell line, but not in primary thyroid tumours	Oncogene	0001923534
Takahashi T;Takahashi T;Suzuki H;Hida T;Sekido Y;Ariyoshi Y;Ueda R;	1991	The p53 gene is very frequently mutated in small-cell lung cancer with a distinct nucleotide substitution pattern	Oncogene	0001656362
Jonveaux P;Fenaux P;Quiquandon I;Pignon JM;Lai JL;Loucheux-Lefebvre MH;Goossens M;Bauters F;Berger R;	1991	Mutations in the p53 gene in myelodysplastic syndromes	Oncogene	0001766671
Shaw P;Tardy S;Benito E;Obrador A;Costa J;	1991	Occurrence of Ki-ras and p53 mutations in primary colorectal tumors	Oncogene	0001945416
Casson AG;Mukhopadhyay T;Cleary KR;Ro JY;Levin B;Roth JA;	1991	p53 gene mutations in Barrett's epithelium and esophageal cancer	Cancer Res	0001868473
Murakami Y;Hayashi K;Hirohashi S;Sekiya T;	1991	Aberrations of the tumor suppressor p53 and retinoblastoma genes in human hepatocellular carcinomas	Cancer Res	0001655254
Murakami Y;Hayashi K;Sekiya T;	1991	Detection of aberrations of the p53 alleles and the gene transcript in human tumor cell lines by single-strand conformation polymorphism analysis	Cancer Res	0002054775
Lehman TA;Bennett WP;Metcalf RA;Welsh JA;Ecker J;Modali RV;Ullrich S;Romano JW;Appella E;Testa JR;	1991	p53 mutations, ras mutations, and p53-heat shock 70 protein complexes in human lung carcinoma cell lines	Cancer Res	0001855224
Hollstein MC;Peri L;Mandard AM;Welsh JA;Montesano R;Metcalf RA;Bak M;Harris CC;	1991	Genetic analysis of human esophageal tumors from two high incidence geographic areas: frequent p53 base substitutions and absence of ras mutations	Cancer Res	0001855226
Tamura G;Kihana T;Nomura K;Terada M;Sugimura T;Hirohashi S;	1991	Detection of frequent p53 gene mutations in primary gastric cancer by cell sorting and polymerase chain reaction single-strand conformation polymorphism analysis	Cancer Res	0002032245
Shirasawa S;Urabe K;Yanagawa Y;Toshitani K;Iwama T;Sasazuki T;	1991	p53 gene mutations in colorectal tumors from patients with familial polyposis coli	Cancer Res	0001851662
Davidoff AM;Kerns BJ;Iglehart JD;Marks JR;	1991	Maintenance of p53 alterations throughout breast cancer progression	Cancer Res	0001850660
Ohgaki H;Eibl RH;Wiestler OD;Yasargil MG;Newcomb EW;Kleihues P;	1991	p53 mutations in nonastrocytic human brain tumors	Cancer Res	0001933879
Saylors RL;Sidransky D;Friedman HS;Bigner SH;Bigner DD;Vogelstein B;Brodeur GM;	1991	Infrequent p53 gene mutations in medulloblastomas	Cancer Res	0001873817
Brachman DG;Hallahan DE;Beckett MA;Yandell DW;Weichselbaum RR;	1991	p53 gene mutations and abnormal retinoblastoma protein in radiation- induced human sarcomas	Cancer Res	0001933904
Osborne RJ;Merlo GR;Mitsudomi T;Venesio T;Liscia DS;Cappa AP;Chiba I;Takahashi T;Nau MM;Callahan R;	1991	Mutations in the p53 gene in primary human breast cancers	Cancer Res	0001682043
Isaacs WB;Carter BS;Ewing CM;	1991	Wild-type p53 suppresses growth of human prostate cancer cells containing mutant p53 alleles	Cancer Res	0001873816
Okamoto A;Sameshima Y;Yokoyama S;Terashima Y;Sugimura T;Terada M;Yokota J;	1991	Frequent allelic losses and mutations of the p53 gene in human ovarian cancer	Cancer Res	0001680546
Cote RJ;Jhanwar SC;Novick S;Pellicer A;	1991	Genetic alterations of the p53 gene are a feature of malignant mesotheliomas (published erratum appears in Cancer Res 1991 Dec 1;51(23 Pt 1):6399)	Cancer Res	0001913660
Okamoto A;Sameshima Y;Yamada Y;Teshima S;Terashima Y;Terada M;Yokota J;	1991	Allelic loss on chromosome 17p and p53 mutations in human endometrial carcinoma of the uterus	Cancer Res	0001913680
Yamada Y;Yoshida T;Hayashi K;Sekiya T;Yokota J;Hirohashi S;Nakatani K;Nakano H;Sugimura T;Terada M;	1991	p53 gene mutations in gastric cancer metastases and in gastric cancer cell lines derived from metastases	Cancer Res	0001933850
Yaginuma Y;Westphal H;	1991	Analysis of the p53 gene in human uterine carcinoma cell lines	Cancer Res	0001660340
Kastan MB;Onyekwere O;Sidransky D;Vogelstein B;Craig RW;	1991	Participation of p53 protein in the cellular response to DNA damage	Cancer Res	0001933891
Barton CM;Staddon SL;Hughes CM;Hall PA;O'Sullivan C;Kloppel G;Theis B;Russell RC;Neoptolemos J;Williamson RC;	1991	Abnormalities of the p53 tumour suppressor gene in human pancreatic cancer (published erratum appears in Br J Cancer 1992 Mar;65(3):485)	Br J Cancer	0001764370
Sugito S;Yamato K;Sameshima Y;Yokota J;Yano S;Miyoshi I;	1991	Adult T-cell leukemia: structures and expression of the p53 gene	Int J Cancer	0001959992
Pierceall WE;Mukhopadhyay T;Goldberg LH;Ananthaswamy HN;	1991	Mutations in the p53 tumor suppressor gene in human cutaneous squamous cell carcinomas	Mol Carcinog	0001793482
Ahuja H;Bar-Eli M;Arlin Z;Advani S;Allen SL;Goldman J;Snyder D;Foti A;Cline M;	1991	The spectrum of molecular alterations in the evolution of chronic myelocytic leukemia	J Clin Invest	0002040694
Nagai H;Kinoshita T;Imamura J;Murakami Y;Hayashi K;Mukai K;Ikeda S;Tobinai K;Saito H;Shimoyama M;	1991	Genetic alteration of p53 in some patients with adult T-cell leukemia	Jpn J Cancer Res	0001778765
Volkenandt M;Schlegel U;Nanus DM;Albino AP;	1991	Mutational analysis of the human p53 gene in malignant melanoma	Pigment Cell Res	0001924172
Kim JH;Takahashi T;Chiba I;Park JG;Birrer MJ;Roh JK;De Lee H;Kim JP;Minna JD;Gazdar AF;	1991	Occurrence of p53 gene abnormalities in gastric carcinoma tumors and cell lines	J Natl Cancer Inst	0001676761
Kovach JS;McGovern RM;Cassady JD;Swanson SK;Wold LE;Vogelstein B;Sommer SS;	1991	Direct sequencing from touch preparations of human carcinomas: analysis of p53 mutations in breast carcinomas	J Natl Cancer Inst	0001712853
Han ES;Moyer MP;Naylor S;Sakaguchi AY;	1991	Mutation in the TP53 gene in colorectal carcinoma detected by polymerase chain reaction	Genes Chromosomes Cancer	0001958596
Chung R;Whaley J;Kley N;Anderson K;Louis D;Menon A;Hettlich C;Freiman R;Hedley-Whyte ET;Martuza R;	1991	TP53 gene mutations and 17p deletions in human astrocytomas	Genes Chromosomes Cancer	0001686725
Gaidano G;Ballerini P;Gong JZ;Inghirami G;Neri A;Newcomb EW;Magrath IT;Knowles DM;Dalla-Favera R;	1991	p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia	Proc Natl Acad Sci U S A	0002052620
Scheffner M;Munger K;Byrne JC;Howley PM;	1991	The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines	Proc Natl Acad Sci U S A	0001648218
Feinstein E;Cimino G;Gale RP;Alimena G;Berthier R;Kishi K;Goldman J;Zaccaria A;Berrebi A;Canaani E;	1991	p53 in chronic myelogenous leukemia in acute phase	Proc Natl Acad Sci U S A	0002068108
Brash DE;Rudolph JA;Simon JA;Lin A;McKenna GJ;Baden HP;Halperin AJ;Ponten J;	1991	A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma	Proc Natl Acad Sci U S A	0001946433
Borresen AL;Hovig E;Smith-Sorensen B;Malkin D;Lystad S;Andersen TI;Nesland JM;Isselbacher KJ;Friend SH;	1991	Constant denaturant gel electrophoresis as a rapid screening technique for p53 mutations	Proc Natl Acad Sci U S A	0001924299
Davidoff AM;Humphrey PA;Iglehart JD;Marks JR;	1991	Genetic basis for p53 overexpression in human breast cancer	Proc Natl Acad Sci U S A	0002052583
Chen LC;Neubauer A;Kurisu W;Waldman FM;Ljung BM;Goodson W;Goldman ES;Moore D;Balazs M;Liu E;	1991	Loss of heterozygosity on the short arm of chromosome 17 is associated with high proliferative capacity and DNA aneuploidy in primary human breast cancer	Proc Natl Acad Sci U S A	0001673792
Runnebaum IB;Nagarajan M;Bowman M;Soto D;Sukumar S;	1991	Mutations in p53 as potential molecular markers for human breast cancer	Proc Natl Acad Sci U S A	0001961733
Ishioka C;Sato T;Gamoh M;Suzuki T;Shibata H;Kanamaru R;Wakui A;Yamazaki T;	1991	Mutations of the P53 gene, including an intronic point mutation, in colorectal tumors	Biochem Biophys Res Commun	0001647768
Hayashi Y;Yamashita J;Yamaguchi K;	1991	Timing and role of p53 gene mutation in the recurrence of glioma	Biochem Biophys Res Commun	0001953716
Yin Y;Tainsky MA;Bischoff FZ;Strong LC;Wahl GM;	1992	Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles	Cell	1525830
Sakashita A;Hattori T;Miller CW;Suzushima H;Asou N;Takatsuki K;Koeffler HP;	1992	Mutations of the p53 gene in adult T-cell leukemia	Blood	0001730092
Cesarman E;Chadburn A;Inghirami G;Gaidano G;Knowles DM;	1992	Structural and functional analysis of oncogenes and tumor suppressor genes in adult T-cell leukemia/lymphoma shows frequent p53 mutations	Blood	0001361372
Sugimoto K;Toyoshima H;Sakai R;Miyagawa K;Hagiwara K;Ishikawa F;Takaku F;Yazaki Y;Hirai H;	1992	Frequent mutations in the p53 gene in human myeloid leukemia cell lines	Blood	0001571549
Ichikawa A;Hotta T;Takagi N;Tsushita K;Kinoshita T;Nagai H;Murakami Y;Hayashi K;Saito H;	1992	Mutations of p53 gene and their relation to disease progression in B- cell lymphoma	Blood	0001375111
Crook T;Vousden KH;	1992	Properties of p53 mutations detected in primary and secondary cervical cancers suggest mechanisms of metastasis and involvement of environmental carcinogens	EMBO J	0001327751
Effert PJ;Neubauer A;Walther PJ;Liu ET;	1992	Alterations of the P53 gene are associated with the progression of a human prostate carcinoma	J Urol	0001347085
Vahakangas KH;Samet JM;Metcalf RA;Welsh JA;Bennett WP;Lane DP;Harris CC;	1992	Mutations of p53 and ras genes in radon-associated lung cancer from uranium miners	Lancet	0001347094
Borresen AL;Helland A;Nesland J;Holm R;Trope C;Kaern J;	1992	Papillomaviruses, p53, and cervical cancer (letter) (published erratum appears in Lancet 1992 Aug 1;340(8814):318)	Lancet	0001350005
Crook T;Wrede D;Tidy JA;Mason WP;Evans DJ;Vousden KH;	1992	Clonal p53 mutation in primary cervical cancer: association with human- papillomavirus-negative tumours	Lancet	0001349102
Lunec J;Challen C;Wright C;Mellon K;Neal DE;	1992	c-erbB-2 amplification and identical p53 mutations in concomitant transitional carcinomas of renal pelvis and urinary bladder	Lancet	0001346710
Sidransky D;Mikkelsen T;Schwechheimer K;Rosenblum ML;Cavanee W;Vogelstein B;	1992	Clonal expansion of p53 mutant cells is associated with brain tumour progression	Nature	0001311419
Effert P;McCoy R;Abdel-Hamid M;Flynn K;Zhang Q;Busson P;Tursz T;Liu E;Raab-Traub N;	1992	Alterations of the p53 gene in nasopharyngeal carcinoma	J Virol	0001349927
Ludwig L;Schulz AS;Janssen JW;Grunewald K;Bartram CR;	1992	P53 mutations in myelodysplastic syndromes	Leukemia	0001453775
Bi S;Hughes T;Bungey J;Chase A;de Fabritiis P;Goldman JM;	1992	p53 in chronic myeloid leukemia cell lines	Leukemia	0001640738
Fenaux P;Jonveaux P;Quiquandon I;Preudhomme C;Lai JL;Vanrumbeke M;Loucheux-Lefebvre MH;Bauters F;Berger R;Kerckaert JP;	1992	Mutations of the p53 gene in B-cell lymphoblastic acute leukemia: a report on 60 cases	Leukemia	0001736012
Ruggeri B;Zhang SY;Caamano J;DiRado M;Flynn SD;Klein-Szanto AJ;	1992	Human pancreatic carcinomas and cell lines reveal frequent and multiple alterations in the p53 and Rb-1 tumor-suppressor genes	Oncogene	0001630814
Davidoff AM;Pence JC;Shorter NA;Iglehart JD;Marks JR;	1992	Expression of p53 in human neuroblastoma- and neuroepithelioma-derived cell lines	Oncogene	0001741160
Maestro R;Dolcetti R;Gasparotto D;Doglioni C;Pelucchi S;Barzan L;Grandi E;Boiocchi M;	1992	High frequency of p53 gene alterations associated with protein overexpression in human squamous cell carcinoma of the larynx	Oncogene	0001594246
Mazars GR;Portier M;Zhang XG;Jourdan M;Bataille R;Theillet C;Klein B;	1992	Mutations of the p53 gene in human myeloma cell lines (published erratum appears in Oncogene 1993 Apr;8(4):1107)	Oncogene	0001373872
D'Amico D;Carbone D;Mitsudomi T;Nau M;Fedorko J;Russell E;Johnson B;Buchhagen D;Bodner S;Phelps R;	1992	High frequency of somatically acquired p53 mutations in small-cell lung cancer cell lines and tumors	Oncogene	0001312696
Mitsudomi T;Steinberg SM;Nau MM;Carbone D;D'Amico D;Bodner S;Oie HK;Linnoila RI;Mulshine JL;Minna JD;	1992	p53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features	Oncogene	0001311061
Sameshima Y;Matsuno Y;Hirohashi S;Shimosato Y;Mizoguchi H;Sugimura T;Terada M;Yokota J;	1992	Alterations of the p53 gene are common and critical events for the maintenance of malignant phenotypes in small-cell lung carcinoma	Oncogene	0001312700
Sakai E;Tsuchida N;	1992	Most human squamous cell carcinomas in the oral cavity contain mutated p53 tumor-suppressor genes	Oncogene	0001570156
Bodner SM;Minna JD;Jensen SM;D'Amico D;Carbone D;Mitsudomi T;Fedorko J;Buchhagen DL;Nau MM;Gazdar AF;	1992	Expression of mutant p53 proteins in lung cancer correlates with the class of p53 gene mutation	Oncogene	0001565469
Portier M;Moles JP;Mazars GR;Jeanteur P;Bataille R;Klein B;Theillet C;	1992	p53 and RAS gene mutations in multiple myeloma	Oncogene	0001461658
Sundaresan V;Ganly P;Hasleton P;Rudd R;Sinha G;Bleehen NM;Rabbitts P;	1992	p53 and chromosome 3 abnormalities, characteristic of malignant lung tumours, are detectable in preinvasive lesions of the bronchus	Oncogene	0001408139
Ullrich SJ;Mercer WE;Appella E;	1992	Human wild-type p53 adopts a unique conformational and phosphorylation state in vivo during growth arrest of glioblastoma cells	Oncogene	0001630823
Felix CA;Kappel CC;Mitsudomi T;Nau MM;Tsokos M;Crouch GD;Nisen PD;Winick NJ;Helman LJ;	1992	Frequency and diversity of p53 mutations in childhood rhabdomyosarcoma	Cancer Res	0001559227
Kohler MF;Berchuck A;Davidoff AM;Humphrey PA;Dodge RK;Iglehart JD;Soper JT;Clarke-Pearson DL;Bast RC;Marks JR;	1992	Overexpression and mutation of p53 in endometrial carcinoma	Cancer Res	0001540970
Cunningham J;Lust JA;Schaid DJ;Bren GD;Carpenter HA;Rizza E;Kovach JS;Thibodeau SN;	1992	Expression of p53 and 17p allelic loss in colorectal carcinoma	Cancer Res	0001551126
Suzuki H;Takahashi T;Kuroishi T;Suyama M;Ariyoshi Y;Takahashi T;Ueda R;	1992	p53 mutations in non-small cell lung cancer in Japan: association between mutations and smoking	Cancer Res	0001310070
Frankel RH;Bayona W;Koslow M;Newcomb EW;	1992	p53 mutations in human malignant gliomas: comparison of loss of heterozygosity with mutation frequency	Cancer Res	0001347252
Fults D;Brockmeyer D;Tullous MW;Pedone CA;Cawthon RM;	1992	p53 mutation and loss of heterozygosity on chromosomes 17 and 10 during human astrocytoma progression	Cancer Res	0001346255
Scorsone KA;Zhou YZ;Butel JS;Slagle BL;	1992	p53 mutations cluster at codon 249 in hepatitis B virus-positive hepatocellular carcinomas from China	Cancer Res	0001311638
Kikuchi-Yanoshita R;Konishi M;Ito S;Seki M;Tanaka K;Maeda Y;Iino H;Fukayama M;Koike M;Mori T;	1992	Genetic changes of both p53 alleles associated with the conversion from colorectal adenoma to early carcinoma in familial adenomatous polyposis and non-familial adenomatous polyposis patients	Cancer Res	0001319835
Miller CW;Simon K;Aslo A;Kok K;Yokota J;Buys CH;Terada M;Koeffler HP;	1992	p53 mutations in human lung tumors	Cancer Res	0001312896
Ito T;Seyama T;Mizuno T;Tsuyama N;Hayashi T;Hayashi Y;Dohi K;Nakamura N;Akiyama M;	1992	Unique association of p53 mutations with undifferentiated but not with differentiated carcinomas of the thyroid gland	Cancer Res	0001737400
Metcalf RA;Welsh JA;Bennett WP;Seddon MB;Lehman TA;Pelin K;Linnainmaa K;Tammilehto L;Mattson K;Gerwin BI;	1992	p53 and Kirsten-ras mutations in human mesothelioma cell lines	Cancer Res	0001568228
Kishimoto Y;Murakami Y;Shiraishi M;Hayashi K;Sekiya T;	1992	Aberrations of the p53 tumor suppressor gene in human non-small cell carcinomas of the lung	Cancer Res	0001324794
Spruck CH;Tsai YC;Huang DP;Yang AS;Rideout WM;Gonzalez-Zulueta M;Choi P;Lo KW;Yu MC;Jones PA;	1992	Absence of p53 gene mutations in primary nasopharyngeal carcinomas	Cancer Res	0001511442
Rady P;Scinicariello F;Wagner RF;Tyring SK;	1992	p53 mutations in basal cell carcinomas	Cancer Res	0001617650
Kress S;Jahn UR;Buchmann A;Bannasch P;Schwarz M;	1992	p53 Mutations in human hepatocellular carcinomas from Germany	Cancer Res	0001317262
Coles C;Condie A;Chetty U;Steel CM;Evans HJ;Prosser J;	1992	p53 mutations in breast cancer	Cancer Res	0001394133
Bennett WP;Hollstein MC;Metcalf RA;Welsh JA;He A;Zhu SM;Kusters I;Resau JH;Trump BF;Lane DP;	1992	p53 mutation and protein accumulation during multistage human esophageal carcinogenesis	Cancer Res	0001394236
Sheu JC;Huang GT;Lee PH;Chung JC;Chou HC;Lai MY;Wang JT;Lee HS;Shih LN;Yang PM;	1992	Mutation of p53 gene in hepatocellular carcinoma in Taiwan	Cancer Res	0001327523
Yoshimoto K;Iwahana H;Fukuda A;Sano T;Saito S;Itakura M;	1992	Role of p53 mutations in endocrine tumorigenesis: mutation detection by polymerase chain reaction-single strand conformation polymorphism	Cancer Res	0001516062
Mazars R;Spinardi L;BenCheikh M;Simony-Lafontaine J;Jeanteur P;Theillet C;	1992	p53 mutations occur in aggressive breast cancer	Cancer Res	0001617667
Matozaki T;Sakamoto C;Suzuki T;Matsuda K;Uchida T;Nakano O;Wada K;Nishisaki H;Konda Y;Nagao M;	1992	p53 gene mutations in human gastric cancer: wild-type p53 but not mutant p53 suppresses growth of human gastric cancer cells	Cancer Res	0001322785
Brachman DG;Graves D;Vokes E;Beckett M;Haraf D;Montag A;Dunphy E;Mick R;Yandell D;Weichselbaum RR;	1992	Occurrence of p53 gene deletions and human papilloma virus infection in human head and neck cancer	Cancer Res	0001324797
von Deimling A;Eibl RH;Ohgaki H;Louis DN;von Ammon K;Petersen I;Kleihues P;Chung RY;Wiestler OD;Seizinger BR;	1992	p53 mutations are associated with 17p allelic loss in grade II and grade III astrocytoma	Cancer Res	0001349850
Fujita M;Inoue M;Tanizawa O;Iwamoto S;Enomoto T;	1992	Alterations of the p53 gene in human primary cervical carcinoma with and without human papillomavirus infection	Cancer Res	0001327506
Bhatia KG;Gutierrez MI;Huppi K;Siwarski D;Magrath IT;	1992	The pattern of p53 mutations in Burkitt's lymphoma differs from that of solid tumors	Cancer Res	0001638540
Yaginuma Y;Westphal H;	1992	Abnormal structure and expression of the p53 gene in human ovarian carcinoma cell lines	Cancer Res	0001638534
Oda T;Tsuda H;Scarpa A;Sakamoto M;Hirohashi S;	1992	p53 gene mutation spectrum in hepatocellular carcinoma	Cancer Res	0001330291
Toguchida J;Yamaguchi T;Ritchie B;Beauchamp RL;Dayton SH;Herrera GE;Yamamuro T;Kotoura Y;Sasaki MS;Little JB;	1992	Mutation spectrum of the p53 gene in bone and soft tissue sarcomas	Cancer Res	0001423262
Nakai H;Misawa S;Toguchida J;Yandell DW;Ishizaki K;	1992	Frequent p53 gene mutations in blast crisis of chronic myelogenous leukemia, especially in myeloid crisis harboring loss of a chromosome 17p	Cancer Res	0001423304
Sozzi G;Miozzo M;Donghi R;Pilotti S;Cariani CT;Pastorino U;Della PG;Pierotti MA;	1992	Deletions of 17p and p53 mutations in preneoplastic lesions of the lung	Cancer Res	0001394234
Somers KD;Merrick MA;Lopez ME;Incognito LS;Schechter GL;Casey G;	1992	Frequent p53 mutations in head and neck cancer	Cancer Res	0001394225
Jung M;Notario V;Dritschilo A;	1992	Mutations in the p53 gene in radiation-sensitive and -resistant human squamous carcinoma cells	Cancer Res	0001423286
Reuvekamp PT;Stulp RP;Schraffordt-Koops H;Oosterhuis JW;Scheffer H;Buys CH;	1992	Analysis of a metastasizing testicular mixed gonadal stromal tumor with osteosarcoma components suggests that a malignant tumor with the histology of osteosarcoma may develop without primary involvement of RB1 and TP53	Cancer Res	0001423318
Fujimoto K;Yamada Y;Okajima E;Kakizoe T;Sasaki H;Sugimura T;Terada M;	1992	Frequent association of p53 gene mutation in invasive bladder cancer	Cancer Res	0001540947
Mok CH;Tsao SW;Knapp RC;Fishbaugh PM;Lau CC;	1992	Unifocal origin of advanced human epithelial ovarian cancers	Cancer Res	0001516069
Saxena A;Clark WC;Robertson JT;Ikejiri B;Oldfield EH;Ali IU;	1992	Evidence for the involvement of a potential second tumor suppressor gene on chromosome 17 distinct from p53 in malignant astrocytomas (published erratum appears in Cancer Res 1993 Mar 15;53(6):1472)	Cancer Res	0001358438
Maehle L;Metcalf RA;Ryberg D;Bennett WP;Harris CC;Haugen A;	1992	Altered p53 gene structure and expression in human epithelial cells after exposure to nickel	Cancer Res	0001727381
Challen C;Lunec J;Warren W;Collier J;Bassendine MF;	1992	Analysis of the p53 tumor-suppressor gene in hepatocellular carcinomas from Britain	Hepatology	0001332921
Tobal K;Warren W;Cooper CS;McCartney A;Hungerford J;Lightman S;	1992	Increased expression and mutation of p53 in choroidal melanoma	Br J Cancer	0001419633
Seruca R;David L;Holm R;Nesland JM;Fangan BM;Castedo S;Sobrinho-Simoes M;Borresen AL;	1992	P53 mutations in gastric carcinomas	Br J Cancer	0001586599
Chandar N;Billig B;McMaster J;Novak J;	1992	Inactivation of p53 gene in human and murine osteosarcoma cells	Br J Cancer	1739619
Chang YS;Lin YJ;Tsai CN;Shu CH;Tsai MS;Choo KB;Liu ST;	1992	Detection of mutations in the p53 gene in human head and neck carcinomas by single strand conformation polymorphism analysis	Cancer Lett	0001336431
Greenwald BD;Hung Y;Baum R;Meltzer SJ;	1992	Barrett's carcinoma in a 25-year-old man with point mutation of the p53 tumor suppressor gene	Int J Oncol	21584541
Sakai E;Rikimaru K;Ueda M;Matsumoto Y;Ishii N;Enomoto S;Yamamoto H;Tsuchida N;	1992	The p53 tumor-suppressor gene and ras oncogene mutations in oral squamous-cell carcinoma	Int J Cancer	0001459726
Risinger JI;Dent GA;Ignar-Trowbridge D;McLachlan JA;Tsao MS;Senterman M;Boyd J;	1992	p53 gene mutations in human endometrial carcinoma	Mol Carcinog	0001497800
Fenaux P;Preudhomme C;Quiquandon I;Jonveaux P;Lai JL;Vanrumbeke M;Loucheux-Lefebvre MH;Bauters F;Berger R;Kerckaert JP;	1992	Mutations of the P53 gene in acute myeloid leukaemia	Br J Haematol	0001550773
Mori N;Wada M;Yokota J;Terada M;Okada M;Teramura M;Masuda M;Hoshino S;Motoji T;Oshimi K;	1992	Mutations of the p53 tumour suppressor gene in haematologic neoplasms	Br J Haematol	0001643020
Preudhomme C;Facon T;Zandecki M;Vanrumbeke M;Lai JL;Nataf E;Loucheux-Lefebvre MH;Kerckaert JP;Fenaux P;	1992	Rare occurrence of P53 gene mutations in multiple myeloma	Br J Haematol	0001390218
Hu G;Zhang W;Deisseroth AB;	1992	P53 gene mutations in acute myelogenous leukaemia	Br J Haematol	0001390233
Felix CA;Nau MM;Takahashi T;Mitsudomi T;Chiba I;Poplack DG;Reaman GH;Cole DE;Letterio JJ;Whang-Peng J;	1992	Hereditary and acquired p53 gene mutations in childhood acute lymphoblastic leukemia	J Clin Invest	0001737852
Imazeki F;Omata M;Nose H;Ohto M;Isono K;	1992	p53 gene mutations in gastric and esophageal cancers	Gastroenterology	0001499939
Suzuki Y;Tamura G;Satodate R;Fujioka T;	1992	Infrequent mutation of p53 gene in human renal cell carcinoma detected by polymerase chain reaction single-strand conformation polymorphism analysis	Jpn J Cancer Res	0001582882
Kihana T;Tsuda H;Teshima S;Okada S;Matsuura S;Hirohashi S;	1992	High incidence of p53 gene mutation in human ovarian cancer and its association with nuclear accumulation of p53 protein and tumor DNA aneuploidy	Jpn J Cancer Res	0001429209
Tamura G;Maesawa C;Suzuki Y;Satodate R;Ishida K;Saito K;	1992	p53 gene mutations in esophageal cancer detected by polymerase chain reaction single-strand conformation polymorphism analysis	Jpn J Cancer Res	0001644659
Yana I;Nakamura T;Shin E;Karakawa K;Kurahashi H;Kurita Y;Kobayashi T;Mori T;Nishisho I;Takai S;	1992	Inactivation of the p53 gene is not required for tumorigenesis of medullary thyroid carcinoma or pheochromocytoma	Jpn J Cancer Res	0001483923
Tsuda H;Hirohashi S;	1992	Frequent occurrence of p53 gene mutations in uterine cancers at advanced clinical stage and with aggressive histological phenotypes	Jpn J Cancer Res	0001336492
Naito M;Satake M;Sakai E;Hirano Y;Tsuchida N;Kanzaki H;Ito Y;Mori T;	1992	Detection of p53 gene mutations in human ovarian and endometrial cancers by polymerase chain reaction-single strand conformation polymorphism analysis	Jpn J Cancer Res	0001333465
Nakamura T;Yana I;Kobayashi T;Shin E;Karakawa K;Fujita S;Miya A;Mori T;Nishisho I;Takai S;	1992	p53 gene mutations associated with anaplastic transformation of human thyroid carcinomas	Jpn J Cancer Res	0001483945
Maesawa C;Tamura G;Suzuki Y;Ishida K;Saito K;Satodate R;	1992	Sensitive detection of p53 gene mutations in esophageal endoscopic biopsy specimens by cell sorting combined with polymerase chain reaction single-strand conformation polymorphism analysis	Jpn J Cancer Res	0001483940
Sommer SS;Cunningham J;McGovern RM;Saitoh S;Schroeder JJ;Wold LE;Kovach JS;	1992	Pattern of p53 gene mutations in breast cancers of women of the midwestern United States	J Natl Cancer Inst	1734086
Thor AD;Moore DH;Edgerton SM;Kawasaki ES;Reihsaus E;Lynch HT;Marcus JN;Schwartz L;Chen LC;Mayall BH;	1992	Accumulation of p53 tumor suppressor gene protein: an independent marker of prognosis in breast cancers	J Natl Cancer Inst	0001317462
Lothe RA;Fossli T;Danielsen HE;Stenwig AE;Nesland JM;Gallie B;Borresen AL;	1992	Molecular genetic studies of tumor suppressor gene regions on chromosomes 13 and 17 in colorectal tumors	J Natl Cancer Inst	0001619684
Ruggeri B;Zhang SY;Klein-Szanto AJ;	1992	Molecular and cytogenetic alterations in human pancreatic cancer: the role of tumor suppressor genes	Prog Clin Biol Res	0001528921
Hovig E;Andreassen A;Fangan BM;Borresen AL;	1992	A TP53 mutation detected in cells established from an osteosarcoma, but not in the retinoblastoma of a patient with bilateral retinoblastoma and multiple primary osteosarcomas	Cancer Genet Cytogenet	0001336709
Davidoff AM;Iglehart JD;Marks JR;	1992	Immune response to p53 is dependent upon p53/HSP70 complexes in breast cancers	Proc Natl Acad Sci U S A	0001373500
Moll UM;Riou G;Levine AJ;	1992	Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion	Proc Natl Acad Sci U S A	0001353891
Sun Y;Hegamyer G;Cheng YJ;Hildesheim A;Chen JY;Chen IH;Cao Y;Yao KT;Colburn NH;	1992	An infrequent point mutation of the p53 gene in human nasopharyngeal carcinoma	Proc Natl Acad Sci U S A	0001631151
Iavarone A;Matthay KK;Steinkirchner TM;Israel MA;	1992	Germ-line and somatic p53 gene mutations in multifocal osteogenic sarcoma	Proc Natl Acad Sci U S A	0001349175
Buetow KH;Sheffield VC;Zhu M;Zhou T;Shen FM;Hino O;Smith M;McMahon BJ;Lanier AP;London WT;etal	1992	Low frequency of p53 mutations observed in a diverse collection of primary hepatocellular carcinomas	Proc Natl Acad Sci U S A	0001329103
Matozaki T;Sakamoto C;Matsuda K;Suzuki T;Konda Y;Nakano O;Wada K;Uchida T;Nishisaki H;Nagao M;	1992	Missense mutations and a deletion of the p53 gene in human gastric cancer	Biochem Biophys Res Commun	0001370612
Kondo K;Umemoto A;Akimoto S;Uyama T;Hayashi K;Ohnishi Y;Monden Y;	1992	Mutations in the P53 tumour suppressor gene in primary lung cancer in Japan	Biochem Biophys Res Commun	0001348931
Sander CA;Yano T;Clark HM;Harris C;Longo DL;Jaffe ES;Raffeld M;	1993	p53 mutation is associated with progression in follicular lymphomas	Blood	0008400252
Lo CF;Gaidano G;Louie DC;Offit K;Chaganti RS;Dalla-Favera R;	1993	p53 mutations are associated with histologic transformation of follicular lymphoma	Blood	0008400281
Nakamura H;Said JW;Miller CW;Koeffler HP;	1993	Mutation and protein expression of p53 in acquired immunodeficiency syndrome-related lymphomas	Blood	0008338955
Sugimoto K;Hirano N;Toyoshima H;Chiba S;Mano H;Takaku F;Yazaki Y;Hirai H;	1993	Mutations of the p53 gene in myelodysplastic syndrome (MDS) and MDS- derived leukemia	Blood	0008499637
Trumper LH;Brady G;Bagg A;Gray D;Loke SL;Griesser H;Wagman R;Braziel R;Gascoyne RD;Vicini S;	1993	Single-cell analysis of Hodgkin and Reed-Sternberg cells: molecular heterogeneity of gene expression and p53 mutations	Blood	0008499644
Abo J;Inokuchi K;Dan K;Nomura T;	1993	p53 and N-ras mutations in two new leukemia cell lines established from a patient with multilineage CD7-positive acute leukemia	Blood	0007693050
el Rouby S;Thomas A;Costin D;Rosenberg CR;Potmesil M;Silber R;Newcomb EW;	1993	p53 gene mutation in B-cell chronic lymphocytic leukemia is associated with drug resistance and is independent of MDR1/MDR3 gene expression	Blood	0008241511
Villuendas R;Piris MA;Algara P;Sanchez-Beato M;Sanchez-Verde L;Martinez JC;Orradre JL;Garcia P;Lopez C;Martinez P;	1993	The expression of p53 protein in non-Hodgkin's lymphomas is not always dependent on p53 gene mutations	Blood	0008219204
Wada M;Bartram CR;Nakamura H;Hachiya M;Chen DL;Borenstein J;Miller CW;Ludwig L;Hansen-Hagge TE;Ludwig WD;	1993	Analysis of p53 mutations in a large series of lymphoid hematologic malignancies of childhood	Blood	0008219205
Neri A;Baldini L;Trecca D;Cro L;Polli E;Maiolo AT;	1993	p53 gene mutations in multiple myeloma are associated with advanced forms of malignancy	Blood	0008417784
Mitsudomi T;Lam S;Shirakusa T;Gazdar AF;	1993	Detection and sequencing of p53 gene mutations in bronchial biopsy samples in patients with lung cancer	Chest	0008393397
Hiyama K;Hasegawa K;Ishioka S;Takahashi N;Yamakido M;	1993	An atypical carcinoid tumor of the lung with mutations in the p53 gene and the retinoblastoma gene	Chest	0008222834
Paquette RL;Lee YY;Wilczynski SP;Karmakar A;Kizaki M;Miller CW;Koeffler HP;	1993	Mutations of p53 and human papillomavirus infection in cervical carcinoma	Cancer	0008393371
Nose H;Imazeki F;Ohto M;Omata M;	1993	p53 gene mutations and 17p allelic deletions in hepatocellular carcinoma from Japan	Cancer	0008100480
Effert PJ;McCoy RH;Walther PJ;Liu ET;	1993	p53 gene alterations in human prostate carcinoma	J Urol	0008510267
Wei YD;Jiafu Z;Xi QS;Yongjiang M;Xiulong Z;Daizong L;Jianren G;	1993	P53 gene mutations in Chinese human testicular seminoma	J Urol	8345605
Takeshima Y;Seyama T;Bennett WP;Akiyama M;Tokuoka S;Inai K;Mabuchi K;Land CE;Harris CC;	1993	p53 mutations in lung cancers from non-smoking atomic-bomb survivors (published erratum appears in Lancet 1994 May 21;343(8908):1302)	Lancet	0007902903
Puisieux A;Galvin K;Troalen F;Bressac B;Marcais C;Galun E;Ponchel F;Yakicier C;Ji J;Ozturk M;	1993	Retinoblastoma and p53 tumor suppressor genes in human hepatoma cell lines	FASEB J	0008224613
Helland A;Holm R;Kristensen G;Kaern J;Karlsen F;Trope C;Nesland JM;Borresen AL;	1993	Genetic alterations of the TP53 gene, p53 protein expression and HPV infection in primary cervical carcinomas	J Pathol	0008283348
Sotomatsu M;Hayashi Y;Kawamura M;Yugami S;Shitara T;	1993	Establishment of a new human pre-B acute lymphoblastic leukemia cell line (KMO-90) with 1;19 translocation carrying p53 gene alterations	Leukemia	0008412323
Willems PM;Kuypers aW;Meijerink JP;Holdrinet RS;Mensink EJ;	1993	Sporadic mutations of the p53 gene in multiple myeloma and no evidence for germline mutations in three familial multiple myeloma pedigrees	Leukemia	0008321049
Neubauer A;He M;Schmidt CA;Huhn D;Liu ET;	1993	Genetic alterations in the p53 gene in the blast crisis of chronic myelogenous leukemia: analysis by polymerase chain reaction based techniques	Leukemia	0008464238
Nakai H;Misawa S;Tanaka S;Nishigaki H;Taniwaki M;Yokota S;Horiike S;Takashima T;Seriu T;Nakagawa H;	1993	p53 gene mutations and loss of a chromosome 17p in Philadelphia chromosome (Ph1)-positive acute leukemia	Leukemia	0008412316
Gaidano G;Guerrasio A;Serra A;Carozzi F;Cambrin GR;Petroni D;Saglio G;	1993	Mutations in the P53 and RAS family genes are associated with tumor progression of BCR/ABL negative chronic myeloproliferative disorders	Leukemia	0008321046
Gaidano G;Parsa NZ;Tassi V;Della-Latta P;Chaganti RS;Knowles DM;Dalla-Favera R;	1993	In vitro establishment of AIDS-related lymphoma cell lines: phenotypic characterization, oncogene and tumor suppressor gene lesions, and heterogeneity in Epstein-Barr virus infection	Leukemia	8412324
Hamelin R;Jego N;Laurent-Puig P;Vidaud M;Thomas G;	1993	Efficient screening of p53 mutations by denaturing gradient gel electrophoresis in colorectal tumors	Oncogene	0008336944
Debuire B;Paterlini P;Pontisso P;Basso G;May E;	1993	Analysis of the p53 gene in European hepatocellular carcinomas and hepatoblastomas	Oncogene	0008393166
Kovar H;Auinger A;Jug G;Aryee D;Zoubek A;Salzer-Kuntschik M;Gadner H;	1993	Narrow spectrum of infrequent p53 mutations and absence of MDM2 amplification in Ewing tumours	Oncogene	0008378080
Kalthoff H;Schmiegel W;Roeder C;Kasche D;Schmidt A;Lauer G;Thiele HG;Honold G;Pantel K;Riethmuller G;	1993	p53 and K-RAS alterations in pancreatic epithelial cell lesions	Oncogene	0008426738
Ichii S;Takeda S;Horii A;Nakatsuru S;Miyoshi Y;Emi M;Fujiwara Y;Koyama K;Furuyama J;Utsunomiya J;	1993	Detailed analysis of genetic alterations in colorectal tumors from patients with and without familial adenomatous polyposis (FAP)	Oncogene	0008395678
Hosono S;Chou MJ;Lee CS;Shih C;	1993	Infrequent mutation of p53 gene in hepatitis B virus positive primary hepatocellular carcinomas	Oncogene	0008093978
Moles JP;Moyret C;Guillot B;Jeanteur P;Guilhou JJ;Theillet C;Basset-Seguin N;	1993	p53 gene mutations in human epithelial skin cancers	Oncogene	0008437842
Tominaga O;Hamelin R;Trouvat V;Salmon RJ;Lesec G;Thomas G;Remvikos Y;	1993	Frequently elevated content of immunochemically defined wild-type p53 protein in colorectal adenomas	Oncogene	0008378077
Carroll AG;Voeller HJ;Sugars L;Gelmann EP;	1993	p53 oncogene mutations in three human prostate cancer cell lines	Prostate	0008104329
Dunn JM;Hastrich DJ;Newcomb P;Webb JC;Maitland NJ;Farndon JR;	1993	Correlation between p53 mutations and antibody staining in breast carcinoma	Br J Surg	0008252351
Smith-Sorensen B;Gebhardt MC;Kloen P;McIntyre J;Aguilar F;Cerutti P;Borresen AL;	1993	Screening for TP53 mutations in osteosarcomas using constant denaturant gel electrophoresis (CDGE)	Hum Mutat	0008401536
Schubert EL;Bischoff FZ;Whitaker LL;Pleasants LM;Hansen MF;	1993	A method to isolate DNA from small archival tissue samples for p53 gene analysis	Hum Mutat	0008318988
Miyamoto H;Kubota Y;Shuin T;Torigoe S;Hosaka M;Iwasaki Y;Danenberg K;Danenberg PV;	1993	Analyses of p53 gene mutations in primary human bladder cancer	Oncol Res	0008123944
Boyle JO;Hakim J;Koch W;van der Riet P;Hruban RH;Roa RA;Correo R;Eby YJ;Ruppert JM;Sidransky D;	1993	The incidence of p53 mutations increases with progression of head and neck cancer	Cancer Res	0008402617
Nees M;Homann N;Discher H;Andl T;Enders C;Herold-Mende C;Schuhmann A;Bosch FX;	1993	Expression of mutated p53 occurs in tumor-distant epithelia of head and neck cancer patients: a possible molecular basis for the development of multiple tumors	Cancer Res	0008364914
Sato M;Nishigori C;Zghal M;Yagi T;Takebe H;	1993	Ultraviolet-specific mutations in p53 gene in skin tumors in xeroderma pigmentosum patients	Cancer Res	0008319200
Reiter RE;Anglard P;Liu S;Gnarra JR;Linehan WM;	1993	Chromosome 17p deletions and p53 mutations in renal cell carcinoma	Cancer Res	0008319216
Teneriello MG;Ebina M;Linnoila RI;Henry M;Nash JD;Park RC;Birrer MJ;	1993	p53 and Ki-ras gene mutations in epithelial ovarian neoplasms	Cancer Res	0008319218
Spruck CH;Rideout WM;Olumi AF;Ohneseit PF;Yang AS;Tsai YC;Nichols PW;Horn T;Hermann GG;Steven K;	1993	Distinct pattern of p53 mutations in bladder cancer: relationship to tobacco usage (published erratum appears in Cancer Res 1993 May 15;53(10 Suppl):2427)	Cancer Res	0008439962
Kikuchi T;Rempel SA;Rutz HP;de Tribolet N;Mulligan L;Cavenee WK;Jothy S;Leduy L;Van Meir EG;	1993	Turcot's syndrome of glioma and polyposis occurs in the absence of germ line mutations of exons 5 to 9 of the p53 gene	Cancer Res	0008439970
Milner BJ;Allan LA;Eccles DM;Kitchener HC;Leonard RC;Kelly KF;Parkin DE;Haites NE;	1993	p53 mutation is a common genetic event in ovarian carcinoma	Cancer Res	0008481915
Chung KY;Mukhopadhyay T;Kim J;Casson A;Ro JY;Goepfert H;Hong WK;Roth JA;	1993	Discordant p53 gene mutations in primary head and neck cancers and corresponding second primary cancers of the upper aerodigestive tract	Cancer Res	0008453641
Komuro H;Hayashi Y;Kawamura M;Hayashi K;Kaneko Y;Kamoshita S;Hanada R;Yamamoto K;Hongo T;Yamada M;	1993	Mutations of the p53 gene are involved in Ewing's sarcomas but not in neuroblastomas	Cancer Res	0008221663
Nishida N;Fukuda Y;Kokuryu H;Toguchida J;Yandell DW;Ikenega M;Imura H;Ishizaki K;	1993	Role and mutational heterogeneity of the p53 gene in hepatocellular carcinoma	Cancer Res	0008093350
Renault B;van den Broek M;Fodde R;Wijnen J;Pellegata NS;Amadori D;Khan PM;Ranzani GN;	1993	Base transitions are the most frequent genetic changes at P53 in gastric cancer	Cancer Res	0008495424
Thorlacius S;Borresen AL;Eyfjord JE;	1993	Somatic p53 mutations in human breast carcinomas in an Icelandic population: a prognostic factor	Cancer Res	0008453635
Lai MY;Chang HC;Li HP;Ku CK;Chen PJ;Sheu JC;Huang GT;Lee PH;Chen DS;	1993	Splicing mutations of the p53 gene in human hepatocellular carcinoma	Cancer Res	0008384081
Huang Y;Meltzer SJ;Yin J;Tong Y;Chang EH;Srivastava S;McDaniel T;Boynton RF;Zou ZQ;	1993	Altered messenger RNA and unique mutational profiles of p53 and Rb in human esophageal carcinomas	Cancer Res	0008467510
Bookstein R;MacGrogan D;Hilsenbeck SG;Sharkey F;Allred DC;	1993	p53 is mutated in a subset of advanced-stage prostate cancers	Cancer Res	0008324747
Leach FS;Tokino T;Meltzer P;Burrell M;Oliner JD;Smith S;Hill DE;Sidransky D;Kinzler KW;Vogelstein B;	1993	p53 Mutation and MDM2 amplification in human soft tissue sarcomas	Cancer Res	0008387391
Wagata T;Shibagaki I;Imamura M;Shimada Y;Toguchida J;Yandell DW;Ikenaga M;Tobe T;Ishizaki K;	1993	Loss of 17p, mutation of the p53 gene, and overexpression of p53 protein in esophageal squamous cell carcinomas	Cancer Res	0008094033
Enomoto T;Fujita M;Inoue M;Rice JM;Nakajima R;Tanizawa O;Nomura T;	1993	Alterations of the p53 tumor suppressor gene and its association with activation of the c-K-ras-2 protooncogene in premalignant and malignant lesions of the human uterine endometrium	Cancer Res	0008385572
Habuchi T;Takahashi R;Yamada H;Ogawa O;Kakehi Y;Ogura K;Hamazaki S;Toguchida J;Ishizaki K;Fujita J;	1993	Influence of cigarette smoking and schistosomiasis on p53 gene mutation in urothelial cancer	Cancer Res	0008339293
Imamura J;Bartram CR;Berthold F;Harms D;Nakamura H;Koeffler HP;	1993	Mutation of the p53 gene in neuroblastoma and its relationship with N- myc amplification	Cancer Res	0008358734
Andreassen A;Oyjord T;Hovig E;Holm R;Florenes VA;Nesland JM;Myklebost O;Hoie J;Bruland OS;Borresen AL;	1993	p53 abnormalities in different subtypes of human sarcomas	Cancer Res	0008425179
Tanaka S;Toh Y;Adachi E;Matsumata T;Mori R;Sugimachi K;	1993	Tumor progression in hepatocellular carcinoma may be mediated by p53 mutation	Cancer Res	0008389246
Audrezet MP;Robaszkiewicz M;Mercier B;Nousbaum JB;Bail JP;Hardy E;Volant A;Lozac'h P;Charles JF;Goueron H;	1993	TP53 gene mutation profile in esophageal squamous cell carcinomas	Cancer Res	0008242631
Lohmann DR;Fesseler B;Putz B;Reich U;Bohm J;Prauer H;Wunsch PH;Hofler H;	1993	Infrequent mutations of the p53 gene in pulmonary carcinoid tumors	Cancer Res	0008242638
Brachman DG;Beckett M;Graves D;Haraf D;Vokes E;Weichselbaum RR;	1993	p53 mutation does not correlate with radiosensitivity in 24 head and neck cancer cell lines	Cancer Res	0008339273
O'Connor PM;Jackman J;Jondle D;Bhatia K;Magrath I;Kohn KW;	1993	Role of the p53 tumor suppressor gene in cell cycle arrest and radiosensitivity of Burkitt's lymphoma cell lines	Cancer Res	0008402660
Kar S;Jaffe R;Carr BI;	1993	Mutation at codon 249 of p53 gene in a human hepatoblastoma	Hepatology	0008395458
Hunter SB;Bandea C;Swan D;Abbott K;Varma VA;	1993	Mutations in the p53 gene in human astrocytomas: detection by single- strand conformation polymorphism analysis and direct DNA sequencing	Mod Pathol	0008415589
Scarpa A;Capelli P;Mukai K;Zamboni G;Oda T;Iacono C;Hirohashi S;	1993	Pancreatic adenocarcinomas frequently show p53 gene mutations	Am J Pathol	0008494051
Cesarman E;Inghirami G;Chadburn A;Knowles DM;	1993	High levels of p53 protein expression do not correlate with p53 gene mutations in anaplastic large cell lymphoma	Am J Pathol	0008103295
Lohmann D;Putz B;Reich U;Bohm J;Prauer H;Hofler H;	1993	Mutational spectrum of the p53 gene in human small-cell lung cancer and relationship to clinicopathological data	Am J Pathol	0008384408
Kessis TD;Slebos RJ;Han SM;Shah K;Bosch XF;Munoz N;Hedrick L;Cho KR;	1993	p53 gene mutations and MDM2 amplification are uncommon in primary carcinomas of the uterine cervix	Am J Pathol	0008238255
Caamano J;Zhang SY;Rosvold EA;Bauer B;Klein-Szanto AJ;	1993	p53 alterations in human squamous cell carcinomas and carcinoma cell lines	Am J Pathol	0007682763
Scarpa A;Capelli P;Zamboni G;Oda T;Mukai K;Bonetti F;Martignoni G;Iacono C;Serio G;Hirohashi S;	1993	Neoplasia of the ampulla of Vater. Ki-ras and p53 mutations	Am J Pathol	0008475992
Uchida T;Wada C;Shitara T;Egawa S;Koshiba K;	1993	Infrequent involvement of p53 gene mutations in the tumourigenesis of Japanese prostate cancer	Br J Cancer	0007691145
Rochlitz CF;Heide I;de Kant E;Neubauer A;Schmidt CA;Neuhaus P;Huhn D;Herrmann R;	1993	Molecular alterations in a patient with Turcot's syndrome	Br J Cancer	0008394730
Burns JE;Baird MC;Clark LJ;Burns PA;Edington K;Chapman C;Mitchell R;Robertson G;Soutar D;Parkinson EK;	1993	Gene mutations and increased levels of p53 protein in human squamous cell carcinomas and their cell lines	Br J Cancer	0008390283
Andersen TI;Holm R;Nesland JM;Heimdal KR;Ottestad L;Borresen AL;	1993	Prognostic significance of TP53 alterations in breast carcinoma	Br J Cancer	0008102535
Coursaget P;Depril N;Chabaud M;Nandi R;Mayelo V;LeCann P;Yvonnet B;	1993	High prevalence of mutations at codon 249 of the p53 gene in hepatocellular carcinomas from Senegal	Br J Cancer	0008390289
Casey G;Yamanaka Y;Friess H;Kobrin MS;Lopez ME;Buchler M;Beger HG;Korc M;	1993	p53 mutations are common in pancreatic cancer and are absent in chronic pancreatitis	Cancer Lett	0008513440
Chow VT;Quek HH;Tock EP;	1993	Alternative splicing of the p53 tumor suppressor gene in the Molt-4 T-lymphoblastic leukemia cell line	Cancer Lett	8221626
De Angelis P;Stokke T;Smedshammer L;Lothe RA;Meling GI;Rofstad M;Chen Y;Clausen OPF;	1993	p53 expression is associated with a high degree of tumor DNA aneuploidy and incidence of p53 gene mutation, and is localized tot he aneuploid component in colorectal carcinomas	Int J Oncol	21573365
Peinado MA;Fernandez-Renart M;Capella G;Wilson L;Perucho M;	1993	Mutations in the p53 suppressor gene do not correlate with CK- ras oncogene mutations in colorectal cancer	Int J Oncol
Fushida S;Urano T;Tsuruta H;Yonemura Y;Miyazaki I;Shiku H;	1993	Frequent p53 mutations on exons 5 and 8 in human primary gastric cancer	Int J Oncol	21573592
Lang P;Maurer J;Hoher D;Bornhoft G;Montenarh M;Berdel WE;Thiel E;Kreuser ED;	1993	Mutation and expression of the p53 tumor suppressor gene in tumor samples and cancer cell lines: comparison of non-isotopic direct DNA sequencing, immunoblotting and immunohistochemistry	Int J Oncol	21573561
Seth A;Mariano J;Metcalf R;Li H;Panayiotakis A;Panotopoulou E;Papaevangelou ME;Kottaridis SD;Papas TS;	1993	Relative paucity of p53 gene mutations in male breast carcinomas	Int J Oncol	21573618
Luca M;Lenzi R;Lee-Jackson D;Gutman M;Fidler IJ;Bar-Eli M;	1993	p53 mutations are infrequent and do not correlate with the metastatic potential of human melanoma cells	Int J Oncol	21573319
Newcomb EW;Madonia WJ;Pisharody S;Lang FF;Koslow M;Miller DC;	1993	A correlative study of p53 protein alteration and p53 gene mutation in glioblastoma multiforme	Brain Pathol	0008293182
Weiss J;Schwechheimer K;Cavenee WK;Herlyn M;Arden KC;	1993	Mutation and expression of the p53 gene in malignant melanoma cell lines	Int J Cancer	0008514460
Shieh YS;Nguyen C;Vocal MV;Chu HW;	1993	Tumor-suppressor p53 gene in hepatitis C and B virus-associated human hepatocellular carcinoma	Int J Cancer	0008390407
Hollstein MC;Wild CP;Bleicher F;Chutimataewin S;Harris CC;Srivatanakul P;Montesano R;	1993	p53 mutations and aflatoxin B1 exposure in hepatocellular carcinoma patients from Thailand	Int J Cancer	0008380058
Uchino S;Noguchi M;Ochiai A;Saito T;Kobayashi M;Hirohashi S;	1993	p53 mutation in gastric cancer: a genetic model for carcinogenesis is common to gastric and colorectal cancer	Int J Cancer	0008392033
Honda T;Kato H;Imamura T;Gima T;Nishida J;Sasaki M;Hoshi K;Sato A;Wake N;	1993	Involvement of p53 gene mutations in human endometrial carcinomas	Int J Cancer	0008473053
Ohgaki H;Kleihues P;Heitz PU;	1993	p53 mutations in sporadic adrenocortical tumors	Int J Cancer	0008509216
Anker L;Ohgaki H;Ludeke BI;Herrmann HD;Kleihues P;Westphal M;	1993	p53 protein accumulation and gene mutations in human glioma cell lines	Int J Cancer	0008253536
Ohgaki H;Eibl RH;Schwab M;Reichel MB;Mariani L;Gehring M;Petersen I;Holl T;Wiestler OD;Kleihues P;	1993	Mutations of the p53 tumor suppressor gene in neoplasms of the human nervous system	Mol Carcinog	0008397797
Esteve A;Lehman T;Jiang W;Weinstein IB;Harris CC;Ruol A;Peracchia A;Montesano R;Hollstein M;	1993	Correlation of p53 mutations with epidermal growth factor receptor overexpression and absence of mdm2 amplification in human esophageal carcinomas	Mol Carcinog	0008280379
Enomoto T;Fujita M;Inoue M;Nakazawa-Miyamoto A;Tanizawa O;Nomura T;	1993	Alterations of the Rb gene and its association with Ki-ras activation and p53 inactivation in endometrial adenocarcinoma	Mol Carcinog	0008105795
Kiba T;Tsuda H;Pairojkul C;Inoue S;Sugimura T;Hirohashi S;	1993	Mutations of the p53 tumor suppressor gene and the ras gene family in intrahepatic cholangiocellular carcinomas in Japan and Thailand	Mol Carcinog	0008280380
Raffel C;Thomas GA;Tishler DM;Lassoff S;Allen JC;	1993	Absence of p53 mutations in childhood central nervous system primitive neuroectodermal tumors	Neurosurgery	0008396224
Wu JK;Ye Z;Darras BT;	1993	Frequency of p53 tumor suppressor gene mutations in human primary brain tumors	Neurosurgery	0007903434
Campbell C;Quinn AG;Angus B;Rees JL;	1993	The relation between p53 mutation and p53 immunostaining in non- melanoma skin cancer	Br J Dermatol	0008286219
Buhler-Leclerc M;Gratwohl A;Senn HP;	1993	Occurrence of point mutations in p53 gene is not increased in patients with acute myeloid leukaemia carrying an activating N-ras mutation	Br J Haematol	0008217795
Iwasaka T;Oh-uchida M;Matsuo N;Yokoyama M;Fukuda K;Hara K;Fukuyama K;Hori K;Sugimori H;	1993	Correlation between HPV positivity and state of the p53 gene in cervical carcinoma cell lines	Gynecol Oncol	0008380785
del Arco A;Garcia J;Arribas C;Barrio R;Blazquez MG;Izquierdo JM;Izquierdo M;	1993	Timing of p53 mutations during astrocytoma tumorigenesis	Hum Mol Genet	0008268922
Carrere N;Leblanc RM;Begueret J;Blouin P;Cheyrou A;	1993	A new mutation of exon 5 of the P53 gene in breast cancer	Hum Mol Genet	0008364550
Yeargin J;Cheng J;Yu AL;Gjerset R;Bogart M;Haas M;	1993	P53 mutation in acute T cell lymphoblastic leukemia is of somatic origin and is stable during establishment of T cell acute lymphoblastic leukemia cell lines	J Clin Invest	0008486778
Fagin JA;Matsuo K;Karmakar A;Chen DL;Tang SH;Koeffler HP;	1993	High prevalence of mutations of the p53 gene in poorly differentiated human thyroid carcinomas	J Clin Invest	0008423216
Donghi R;Longoni A;Pilotti S;Michieli P;Della PG;Pierotti MA;	1993	Gene p53 mutations are restricted to poorly differentiated and undifferentiated carcinomas of the thyroid gland	J Clin Invest	0008473515
van den Broek MH;Renault B;Fodde R;Verspaget H;Griffioen G;Khan PM;	1993	Sites and types of p53 mutations in an unselected series of colorectal cancers in The Netherlands	Anticancer Res	0008317886
De Benedetti L;Varesco L;Pellegata NS;Losi L;Gismondi V;Casarino L;Sciallero S;Bonelli L;Biticchi R;Bafico A;	1993	Genetic events in sporadic colorectal adenomas: K-ras and p53 heterozygous mutations are not sufficient for malignant progression	Anticancer Res	0008317895
Bar-Eli M;Abbruzzese JL;Lee-Jackson D;Frost P;	1993	p53 gene mutation spectrum in human unknown primary tumors	Anticancer Res	0008239543
van den Broek MH;Jhanwar SC;Fodde R;Chaganti RS;Meera Khan PM;	1993	p53 mutations in colorectal cancers in the patients of Metropolitan New York	Anticancer Res	0008267380
Petersen I;Ohgaki H;Ludeke BI;Kleihues P;	1993	p53 mutations in phenacetin-associated human urothelial carcinomas	Carcinogenesis	0008222064
Li D;Cao Y;He L;Wang NJ;Gu JR;	1993	Aberrations of p53 gene in human hepatocellular carcinoma from China	Carcinogenesis	0008382111
Lehman TA;Modali R;Boukamp P;Stanek J;Bennett WP;Welsh JA;Metcalf RA;Stampfer MR;Fusenig N;Rogan EM;	1993	p53 mutations in human immortalized epithelial cell lines (published erratum appears in Carcinogenesis 1993 Jul;14(7):1491)	Carcinogenesis	0008504475
Hsu IC;Tokiwa T;Bennett W;Metcalf RA;Welsh JA;Sun T;Harris CC;	1993	p53 gene mutation and integrated hepatitis B viral DNA sequences in human liver cancer cell lines	Carcinogenesis	0008389256
Suzuki Y;Tamura G;	1993	Mutations of the p53 gene in carcinomas of the urinary system	Acta Pathol Jpn	0008109252
Lohmann D;Ruhri C;Schmitt M;Graeff H;Hofler H;	1993	Accumulation of p53 protein as an indicator for p53 gene mutation in breast cancer. Occurrence of false-positives and false-negatives	Diagn Mol Pathol	0008287224
Pilotti S;Donghi R;D'Amato L;Giarola M;Longoni A;Della TG;De Palo G;Pierotti MA;Rilke F;	1993	HPV detection and p53 alteration in squamous cell verrucous malignancies of the lower genital tract	Diagn Mol Pathol	0008118602
Dobashi Y;Sugimura H;Sato A;Hirabayashi T;Kanda H;Kitagawa T;Kawaguchi N;Imamura T;Machinami R;	1993	Possible association of p53 overexpression and mutation with high-grade chondrosarcoma	Diagn Mol Pathol	0008118603
Yin J;Harpaz N;Tong Y;Huang Y;Laurin J;Greenwald BD;Hontanosas M;Newkirk C;Meltzer SJ;	1993	p53 point mutations in dysplastic and cancerous ulcerative colitis lesions	Gastroenterology	0008500720
Yamato K;Oka T;Hiroi M;Iwahara Y;Sugito S;Tsuchida N;Miyoshi I;	1993	Aberrant expression of the p53 tumor suppressor gene in adult T-cell leukemia and HTLV-I-infected cells	Jpn J Cancer Res	0008449826
Konishi M;Kikuchi-Yanoshita R;Tanaka K;Sato C;Tsuruta K;Maeda Y;Koike M;Tanaka S;Nakamura Y;Hattori N;	1993	Genetic changes and histopathological grades in human hepatocellular carcinomas	Jpn J Cancer Res	0008407553
Tsuda H;Iwaya K;Fukutomi T;Hirohashi S;	1993	p53 mutations and c-erbB-2 amplification in intraductal and invasive breast carcinomas of high histologic grade	Jpn J Cancer Res	0008099903
Campbell C;Quinn AG;Ro YS;Angus B;Rees JL;	1993	p53 mutations are common and early events that precede tumor invasion in squamous cell neoplasia of the skin	J Invest Dermatol	0008496613
Kohler MF;Marks JR;Wiseman RW;Jacobs IJ;Davidoff AM;Clarke-Pearson DL;Soper JT;Bast RC;Berchuck A;	1993	Spectrum of mutation and frequency of allelic deletion of the p53 gene in ovarian cancer	J Natl Cancer Inst	0008360934
Navone NM;Troncoso P;Pisters LL;Goodrow TL;Palmer JL;Nichols WW;von Eschenbach AC;Conti CJ;	1993	p53 protein accumulation and gene mutation in the progression of human prostate carcinoma	J Natl Cancer Inst	0007692074
Meyers FJ;Chi SG;Fishman JR;deVere White RW;Gumerlock PH;	1993	p53 mutations in benign prostatic hyperplasia	J Natl Cancer Inst	0007693956
Kohler MF;Nishii H;Humphrey PA;Saski H;Marks J;Bast RC;Clarke-Pearson DL;Boyd J;Berchuck A;	1993	Mutation of the p53 tumor-suppressor gene is not a feature of endometrial hyperplasias	Am J Obstet Gynecol	0008372881
Shiraishi Y;	1993	p53 mutation in fresh lymphocytes, B-lymphoblastoid cell lines and their transformed cell lines originating from Bloom syndrome patients	Cancer Genet Cytogenet	0008330285
Sasa M;Kondo K;Komaki K;Uyama T;Morimoto T;Monden Y;	1993	Frequency of spontaneous p53 mutations (CpG site) in breast cancer in Japan	Breast Cancer Res Treat	0008312582
Elledge RM;Fuqua SA;Clark GM;Pujol P;Allred DC;	1993	William L. McGuire Memorial Symposium. The role and prognostic significance of p53 gene alterations in breast cancer	Breast Cancer Res Treat	0008260732
Kashii T;Mizushima Y;Monno S;Nakagawa K;Kobayashi M;	1993	Gene analysis of K-,H-ras, p53 and retinoblastoma susceptibility genes in human lung cancer cell lines by the polymerase chain reaction/single-strand conformation polymorphism method	J Cancer Res Clin Oncol	0008263009
Zou M;Shi Y;Farid NR;	1993	p53 mutations in all stages of thyroid carcinomas	J Clin endocrinol Metab	0008408453
Louis DN;von Deimling A;Chung RY;Rubio MP;Whaley JM;Eibl RH;Ohgaki H;Wiestler OD;Thor AD;Seizinger BR;	1993	Comparative study of p53 gene and protein alterations in human astrocytic tumors	J Neuropathol Exp Neurol	0008381161
Louis DN;Rubio MP;Correa KM;Gusella JF;von Deimling A;	1993	Molecular genetics of pediatric brain stem gliomas. Application of PCR techniques to small and archival brain tumor specimens	J Neuropathol Exp Neurol	0008103086
Kupryjanczyk J;Thor AD;Beauchamp R;Merritt V;Edgerton SM;Bell DA;Yandell DW;	1993	p53 gene mutations and protein accumulation in human ovarian cancer	Proc Natl Acad Sci U S A	0008506342
Gupta RK;Patel K;Bodmer WF;Bodmer JG;	1993	Mutation of p53 in primary biopsy material and cell lines from Hodgkin disease	Proc Natl Acad Sci U S A	0008464894
Ziegler A;Leffell DJ;Kunala S;Sharma HW;Gailani M;Simon JA;Halperin AJ;Baden HP;Shapiro PE;Bale AE;	1993	Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers	Proc Natl Acad Sci U S A	0008483937
Dumaz N;Drougard C;Sarasin A;Daya-Grosjean L;	1993	Specific UV-induced mutation spectrum in the p53 gene of skin tumors from DNA-repair-deficient xeroderma pigmentosum patients	Proc Natl Acad Sci U S A	0008248141
Zhang S;Feng X;Koga H;Ichikawa T;Abe S;Kumanishi T;	1993	p53 gene mutations in pontine gliomas of juvenile onset	Biochem Biophys Res Commun	0008240361
Lee NK;Ye YW;Chen J;Li X;Waber PG;Nisen PD;	1993	p53, retinoblastoma, and human papillomavirus in squamous cell carcinoma and adjacent normal mucosa of the upper aerodigestive tract	Arch Otolaryngol Head Neck Surg	0008398064
Tohdo H;Yokozaki H;Haruma K;Kajiyama G;Tahara E;	1993	p53 gene mutations in gastric adenomas	Virchows Arch B Cell Pathol Incl Mol Pathol	0008097076
Lohmann DR;Funk A;Niedermeyer HP;Haupel S;Hofler H;	1993	Identification of p53 gene mutations in gastrointestinal and pancreatic carcinoids by nonradioisotopic SSCA	Virchows Arch B Cell Pathol Incl Mol Pathol	0008287125
Farrugia MM;Duan LJ;Reis MD;Ngan BY;Berinstein NL;	1994	Alterations of the p53 tumor suppressor gene in diffuse large cell lymphomas with translocations of the c-MYC and BCL-2 proto-oncogenes	Blood	0008274734
Hsiao MH;Yu AL;Yeargin J;Ku D;Haas M;	1994	Nonhereditary p53 mutations in T-cell acute lymphoblastic leukemia are associated with the relapse phase	Blood	0008180387
Baldini L;Fracchiolla NS;Cro LM;Trecca D;Romitti L;Polli E;Maiolo AT;Neri A;	1994	Frequent p53 gene involvement in splenic B-cell leukemia/lymphomas of possible marginal zone origin	Blood	0008018922
Diccianni MB;Yu J;Hsiao M;Mukherjee S;Shao LE;Yu AL;	1994	Clinical significance of p53 mutations in relapsed T-cell acute lymphoblastic leukemia	Blood	0007949183
Wattel E;Preudhomme C;Hecquet B;Vanrumbeke M;Quesnel B;Dervite I;Morel P;Fenaux P;	1994	p53 mutations are associated with resistance to chemotherapy and short survival in hematologic malignancies	Blood	0007949187
Chozick BS;Weicker ME;Pezzullo JC;Jackson CL;Finkelstein SD;Ambler MW;Epstein MH;Finch PW;	1994	Pattern of mutant p53 expression in human astrocytomas suggests the existence of alternate pathways of tumorigenesis	Cancer	0008293408
Caleffi M;Teague MW;Jensen RA;Vnencak-Jones CL;Dupont WD;Parl FF;	1994	p53 gene mutations and steroid receptor status in breast cancer. Clinicopathologic correlations and prognostic assessment	Cancer	0008156519
Hosoi G;Hara J;Okamura T;Osugi Y;Ishihara S;Fukuzawa M;Okada A;Okada S;Tawa A;	1994	Low frequency of the p53 gene mutations in neuroblastoma	Cancer	0008200007
Voeller HJ;Sugars LY;Pretlow T;Gelmann EP;	1994	p53 oncogene mutations in human prostate cancer specimens	J Urol	0007904314
Taylor JA;Watson MA;Devereux TR;Michels RY;Saccomanno G;Anderson M;	1994	p53 mutation hotspot in radon-associated lung cancer	Lancet	0007903781
Blaszyk H;Vaughn CB;Hartmann A;McGovern RM;Schroeder JJ;Cunningham J;Schaid D;Sommer SS;Kovach JS;	1994	Novel pattern of p53 gene mutations in an American black cohort with high mortality from breast cancer	Lancet	0007909871
Ziegler A;Jonason AS;Leffell DJ;Simon JA;Sharma HW;Kimmelman J;Remington L;Jacks T;Brash DE;	1994	Sunburn and p53 in the onset of skin cancer	Nature	0007997263
Edwards RH;Raab-Traub N;	1994	Alterations of the p53 gene in Epstein-Barr virus-associated immunodeficiency-related lymphomas	J Virol	0008107196
Wada H;Asada M;Nakazawa S;Itoh H;Kobayashi Y;Inoue T;Fukumuro K;Chan LC;Sugita K;Hanada R;	1994	Clonal expansion of p53 mutant cells in leukemia progression in vitro	Leukemia	0008289498
Corradini P;Inghirami G;Astolfi M;Ladetto M;Voena C;Ballerini P;Gu W;Nilsson K;Knowles DM;Boccadoro M;	1994	Inactivation of tumor suppressor genes, p53 and Rb1, in plasma cell dyscrasias	Leukemia	0008182933
Felix CA;Wasserman R;Lange BJ;Brown DL;Nau MM;Cole DE;Minna JD;Poplack DG;	1994	Differentiation stages of childhood acute lymphoblastic leukemias with p53 mutations	Leukemia	0008207991
Preudhomme C;Lubin R;Lepelley P;Vanrumbeke M;Fenaux P;	1994	Detection of serum anti p53 antibodies and their correlation with p53 mutations in myelodysplastic syndromes and acute myeloid leukemia	Leukemia	0008090036
Lepelley P;Preudhomme C;Vanrumbeke M;Quesnel B;Cosson A;Fenaux P;	1994	Detection of p53 mutations in hematological malignancies: comparison between immunocytochemistry and DNA analysis	Leukemia	0008057671
Ng IO;Chung LP;Tsang SW;Lam CL;Lai EC;Fan ST;Ng M;	1994	p53 gene mutation spectrum in hepatocellular carcinomas in Hong Kong Chinese	Oncogene	0008108145
Lee YY;Wilczynski SP;Chumakov A;Chih D;Koeffler HP;	1994	Carcinoma of the vulva: HPV and p53 mutations	Oncogene	0008183560
Moyret C;Theillet C;Puig PL;Moles JP;Thomas G;Hamelin R;	1994	Relative efficiency of denaturing gradient gel electrophoresis and single strand conformation polymorphism in the detection of mutations in exons 5 to 8 of the p53 gene	Oncogene	0008183571
Park DJ;Wilczynski SP;Paquette RL;Miller CW;Koeffler HP;	1994	p53 mutations in HPV-negative cervical carcinoma	Oncogene	0008302581
Volkmann M;Hofmann WJ;Muller M;Rath U;Otto G;Zentgraf H;Galle PR;	1994	p53 overexpression is frequent in European hepatocellular carcinoma and largely independent of the codon 249 hot spot mutation	Oncogene	0008302580
Saitoh S;Cunningham J;De Vries EM;McGovern RM;Schroeder JJ;Hartmann A;Blaszyk H;Wold LE;Schaid D;Sommer SS;	1994	p53 gene mutations in breast cancers in midwestern US women: null as well as missense-type mutations are associated with poor prognosis	Oncogene	0008084591
Cripps KJ;Purdie CA;Carder PJ;White S;Komine K;Bird CC;Wyllie AH;	1994	A study of stabilisation of p53 protein versus point mutation in colorectal carcinoma	Oncogene	0008058340
Lang FF;Miller DC;Pisharody S;Koslow M;Newcomb EW;	1994	High frequency of p53 protein accumulation without p53 gene mutation in human juvenile pilocytic, low grade and anaplastic astrocytomas	Oncogene	0008108140
Wu C;Akiyama Y;Imai K;Miyake S;Nagasaki H;Oto M;Okabe S;Iwama T;Mitamura K;Masumitsu H;	1994	DNA alterations in cells from hereditary non-polyposis colorectal cancer patients	Oncogene	0008108146
Scinicariello F;Dolan MJ;Nedelcu I;Tyring SK;Hilliard JK;	1994	Occurrence of human papillomavirus and p53 gene mutations in Kaposi's sarcoma	Virology	0008030271
Runnebaum IB;Tong XW;Mobus VJ;Kieback DG;Rosenthal HE;Kreienberg R;	1994	p53 mutant His175 identified in a newly established fallopian tube carcinoma cell line secreting interleukin 6	FEBS Lett	0007926016
Runnebaum IB;Tong XW;Moebus V;Heilmann V;Kieback DG;Kreienberg R;	1994	Multiplex PCR screening detects small p53 deletions and insertions in human ovarian cancer cell lines	Hum Genet	0008005584
Aoki T;Takeda S;Yanagisawa A;Kato Y;Ajioka Y;Watanabe H;Kudo S;Nakamura Y;	1994	APC and p53 mutations in de novo colorectal adenocarcinomas	Hum Mutat	0008081386
Bardeesy N;Falkoff D;Petruzzi MJ;Nowak N;Zabel B;Adam M;Aguiar MC;Grundy P;Shows T;Pelletier J;	1994	Anaplastic Wilms' tumour, a subtype displaying poor prognosis, harbours p53 gene mutations	Nat Genet	0008075648
Cooper MJ;Haluschak JJ;Johnson D;Schwartz S;Morrison LJ;Lippa M;Hatzivassiliou G;Tan J;	1994	p53 mutations in bladder carcinoma cell lines	Oncol Res	0007787250
van Meyel DJ;Ramsay DA;Chambers AF;Macdonald DR;Cairncross JG;	1994	Absence of hereditary mutations in exons 5 through 9 of the p53 gene and exon 24 of the neurofibromin gene in families with glioma	Ann Neurol	0008285583
Shin DM;Kim J;Ro JY;Hittelman J;Roth JA;Hong WK;Hittelman WN;	1994	Activation of p53 gene expression in premalignant lesions during head and neck tumorigenesis	Cancer Res	0008275461
Fujimoto Y;Hampton LL;Wirth PJ;Wang NJ;Xie JP;Thorgeirsson SS;	1994	Alterations of tumor suppressor genes and allelic losses in human hepatocellular carcinomas in China	Cancer Res	0007903205
Teramoto T;Satonaka K;Kitazawa S;Fujimori T;Hayashi K;Maeda S;	1994	p53 gene abnormalities are closely related to hepatoviral infections and occur at a late stage of hepatocarcinogenesis	Cancer Res	0008261444
van der Riet P;Karp D;Farmer E;Wei Q;Grossman L;Tokino K;Ruppert JM;Sidransky D;	1994	Progression of basal cell carcinoma through loss of chromosome 9q and inactivation of a single p53 allele	Cancer Res	0008261448
Van Meir EG;Kikuchi T;Tada M;Li H;Diserens AC;Wojcik BE;Huang HJ;Friedmann T;de Tribolet N;Cavenee WK;	1994	Analysis of the p53 gene and its expression in human glioblastoma cells	Cancer Res	0008306326
Malkin D;Sexsmith E;Yeger H;Williams BR;Coppes MJ;	1994	Mutations of the p53 tumor suppressor gene occur infrequently in Wilms tumor	Cancer Res	0008174107
Rasheed BK;McLendon RE;Herndon JE;Friedman HS;Friedman AH;Bigner DD;Bigner SH;	1994	Alterations of the TP53 gene in human gliomas	Cancer Res	0008118823
Pellegata NS;Sessa F;Renault B;Bonato M;Leone BE;Solcia E;Ranzani GN;	1994	K-ras and p53 gene mutations in pancreatic cancer: ductal and nonductal tumors progress through different genetic lesions	Cancer Res	0008137263
Deng G;Chen LC;Schott DR;Thor A;Bhargava V;Ljung BM;Chew K;Smith HS;	1994	Loss of heterozygosity and p53 gene mutations in breast cancer	Cancer Res	0008275488
Mao L;Hruban RH;Boyle JO;Tockman M;Sidransky D;	1994	Detection of oncogene mutations in sputum precedes diagnosis of lung cancer	Cancer Res	0008137272
Redston MS;Caldas C;Seymour AB;Hruban RH;da Costa L;Yeo CJ;Kern SE;	1994	p53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions	Cancer Res	0008187092
Uchida T;Wada C;Wang C;Egawa S;Ohtani H;Koshiba K;	1994	Genomic instability of microsatellite repeats and mutations of H-, K-, and N-ras, and p53 genes in renal cell carcinoma	Cancer Res	0008033084
Gao H;Wang LD;Zhou Q;Hong JY;Huang TY;Yang CS;	1994	p53 tumor suppressor gene mutation in early esophageal precancerous lesions and carcinoma among high-risk populations in Henan, China	Cancer Res	0008044781
Glebov OK;McKenzie KE;White CA;Sukumar S;	1994	Frequent p53 gene mutations and novel alleles in familial breast cancer	Cancer Res	0008033087
Thomas S;Brennan J;Martel G;Frazer I;Montesano R;Sidransky D;Hollstein M;	1994	Mutations in the conserved regions of p53 are infrequent in betel- associated oral cancers from Papua New Guinea	Cancer Res	0008012986
Cornelis RS;van Vliet M;Vos CB;Cleton-Jansen AM;van de Vijver MJ;Peterse JL;Khan PM;Borresen AL;Cornelisse CJ;Devilee P;	1994	Evidence for a gene on 17p13.3, distal to TP53, as a target for allele loss in breast tumors without p53 mutations	Cancer Res	0008033152
Strickler JG;Zheng J;Shu Q;Burgart LJ;Alberts SR;Shibata D;	1994	p53 mutations and microsatellite instability in sporadic gastric cancer: when guardians fail	Cancer Res	0008062274
Adesina AM;Nalbantoglu J;Cavenee WK;	1994	p53 gene mutation and mdm2 gene amplification are uncommon in medulloblastoma	Cancer Res	0007923211
Blount PL;Galipeau PC;Sanchez CA;Neshat K;Levine DS;Yin J;Suzuki H;Abraham JM;Meltzer SJ;Reid BJ;	1994	17p allelic losses in diploid cells of patients with Barrett's esophagus who develop aneuploidy	Cancer Res	0008162566
Correa P;Shiao YH;	1994	Phenotypic and genotypic events in gastric carcinogenesis	Cancer Res	0008137316
Hayashi N;Arakawa H;Nagase H;Yanagisawa A;Kato Y;Ohta H;Takano S;Ogawa M;Nakamura Y;	1994	Genetic diagnosis identifies occult lymph node metastases undetectable by the histopathological method	Cancer Res	0008033106
Ohue M;Tomita N;Monden T;Fujita M;Fukunaga M;Takami K;Yana I;Ohnishi T;Enomoto T;Inoue M;	1994	A frequent alteration of p53 gene in carcinoma in adenoma of colon	Cancer Res	0008062281
Cordon-Cardo C;Latres E;Drobnjak M;Oliva MR;Pollack D;Woodruff JM;Marechal V;Chen J;Brennan MF;Levine AJ;	1994	Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas	Cancer Res	0008306343
O'Malley FP;Vnencak-Jones CL;Dupont WD;Parl F;Manning S;Page DL;	1994	p53 mutations are confined to the comedo type ductal carcinoma in situ of the breast. Immunohistochemical and sequencing data	Lab Invest	0008041120
Bhargava V;Thor A;Deng G;Ljung BM;Moore DH;Waldman F;Benz C;Goodson W;Mayall B;Chew K;	1994	The association of p53 immunopositivity with tumor proliferation and other prognostic indicators in breast cancer	Mod Pathol	0008058709
Li ZH;Zheng J;Weiss LM;Shibata D;	1994	c-k-ras and p53 mutations occur very early in adenocarcinoma of the lung	Am J Pathol	0008311114
Dei Tos AP;Maestro R;Doglioni C;Gasparotto D;Boiocchi M;Laurino L;Fletcher CD;	1994	Ultraviolet-induced p53 mutations in atypical fibroxanthoma	Am J Pathol	0008030743
Latres E;Drobnjak M;Pollack D;Oliva MR;Ramos M;Karpeh M;Woodruff JM;Cordon-Cardo C;	1994	Chromosome 17 abnormalities and TP53 mutations in adult soft tissue sarcomas	Am J Pathol	0008053493
Zheng J;Shu Q;Li ZH;Tsao JI;Weiss LM;Shibata D;	1994	Patterns of p53 mutations in squamous cell carcinoma of the lung. Acquisition at a relatively early age

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