TP53 Database: View Functional / Structural Data in <em>TP53</em> with Annotations

	MUT_ID	hg18_Chr17_coordinates	hg19_Chr17_coordinates	hg38_Chr17_coordinates	ExonIntron	Codon_number	Description	c_description	g_description	g_description_GRCh38	ProtDescription	hgvs_hg19	hgvs_hg38	hgvs_NM_000546	Splice_site	CpG_site	Context_coding_3	Type	WT_nucleotide	Mutant_nucleotide	Mut_rate	WT_codon	Mutant_codon	WT_AA	Mutant_AA	Mut_rateAA	Effect	Polymorphism	COSMIClink	CLINVARlink	TCGA_ICGC_GENIE_count	Hotspot	SNPlink	gnomADlink	SourceDatabases	PubMedlink	Residue_function	Domain_function	Structural_motif	SA	TransactivationClass	DNE_LOFclass	DNEclass	StructureFunctionClass	AGVGDClass	SIFTClass	Polyphen2	BayesDel	REVEL	EffectGroup3	SwissProtLink	WAF1nWT	MDM2nWT	BAXnWT	h1433snWT	AIP1nWT	GADD45nWT	NOXAnWT	P53R2nWT	AAchange	WAF1nWT_Saos2	MDM2nWT_Saos2	BAXnWT_Saos2	h1433snWT_Saos2	AIP1nWT_Saos2	PUMAnWT_Saos2	SubG1nWT_Saos2	Type_ID	AAchange_ID	MutationView_ID	Somatic_count	Germline_count	CellLine_count	SpliceAI_DS_AL	SpliceAI_DS_AG	SpliceAI_DS_DG	SpliceAI_DS_DL	SpliceAI_DP_AG	SpliceAI_DP_AL	SpliceAI_DP_DG	SpliceAI_DP_DL

MUT_ID	hg18_Chr17_coordinates	hg19_Chr17_coordinates	hg38_Chr17_coordinates	ExonIntron	Codon_number	Description	c_description	g_description	g_description_GRCh38	ProtDescription	hgvs_hg19	hgvs_hg38	hgvs_NM_000546	Splice_site	CpG_site	Context_coding_3	Type	WT_nucleotide	Mutant_nucleotide	Mut_rate	WT_codon	Mutant_codon	WT_AA	Mutant_AA	Mut_rateAA	Effect	Polymorphism	COSMIClink	CLINVARlink	TCGA_ICGC_GENIE_count	Hotspot	SNPlink	gnomADlink	SourceDatabases	Residue_function	Domain_function	Structural_motif	TransactivationClass	DNE_LOFclass	DNEclass	StructureFunctionClass	AGVGDClass	SIFTClass	Polyphen2	BayesDel	REVEL	EffectGroup3	WAF1nWT	MDM2nWT	BAXnWT	h1433snWT	AIP1nWT	GADD45nWT	NOXAnWT	P53R2nWT	AAchange	Type_ID	AAchange_ID	MutationView_ID	Somatic_count	Germline_count	CellLine_count	SpliceAI_DS_AL	SpliceAI_DS_AG	SpliceAI_DS_DG	SpliceAI_DS_DL	SpliceAI_DP_AG	SpliceAI_DP_AL	SpliceAI_DP_DG	SpliceAI_DP_DL

2	7520634	7579909	7676591	2-exon	2	G>A	c.4G>A	g.7579909C>T	g.7676591C>T	p.E2K	NC_000017.10:g.7579909C>T	NC_000017.11:g.7676591C>T	NM_000546.5:c.4G>A	no	no	G_A	G:C>A:T	G	A	0.235	GAG	AAG	Glu	Lys	0.235	missense	no	5880108	490172	0	no	769884991	17-7579909-C-T	dbSNP150\|gnomAD\|flossies	NA	Transactivation TAD1	N-term/Transactivation	functional	notDNE_notLOF	NA	NA	C0	Damaging	P	0.149	0.547	2	132.6	147.3	214.2	129.3	91.4	101	166.8	180.9	E2K	9	561	4065	0	0	0	0	0.03	0	0	28	31	-397	-706
3	7520634	7579909	7676591	2-exon	2	G>C	c.4G>C	g.7579909C>G	g.7676591C>G	p.E2Q	NC_000017.10:g.7579909C>G	NC_000017.11:g.7676591C>G	NM_000546.5:c.4G>C	no	no	G_A	G:C>C:G	G	C	0.033	GAG	CAG	Glu	Gln	0.033	missense	no			0	no				NA	Transactivation TAD1	N-term/Transactivation	functional	notDNE_notLOF	NA	NA	C0	Tolerated	B	0.0858	0.558	2	113.1	121.5	163.3	132.9	90.4	99.4	175.5	152.6	E2Q	11	562	4066	0	0	0	0	0.02	0.01	0	28	31	-397	-70
4	7520634	7579909	7676591	2-exon	2	G>T	c.4G>T	g.7579909C>A	g.7676591C>A	p.E2*	NC_000017.10:g.7579909C>A	NC_000017.11:g.7676591C>A	NM_000546.5:c.4G>T	no	no	G_A	G:C>T:A	G	T	0.051	GAG	TAG	Glu	STOP	0.051	nonsense	no			0	no				NA	Transactivation TAD1	N-term/Transactivation	NA	notDNE_LOF	NA	NA	NA	NA	NA			4									E2X	12	564	4067	0	0	0	0.01	0.02	0.02	0.02	28	31	-397	-70
5	7520633	7579908	7676590	2-exon	2	A>C	c.5A>C	g.7579908T>G	g.7676590T>G	p.E2A	NC_000017.10:g.7579908T>G	NC_000017.11:g.7676590T>G	NM_000546.5:c.5A>C	no	no	G_G	A:T>C:G	A	C	0.038	GAG	GCG	Glu	Ala	0.038	missense	no			0	no				NA	Transactivation TAD1	N-term/Transactivation	functional	notDNE_LOF	NA	NA	C0	Damaging	P	0.0985	0.523	2	107.3	117.9	197.3	122.2	93.5	91.9	167	149.6	E2A	6	557	4081	0	0	0	0.02	0	0	0	-522	29	-396	-69
6	7520633	7579908	7676590	2-exon	2	A>G	c.5A>G	g.7579908T>C	g.7676590T>C	p.E2G	NC_000017.10:g.7579908T>C	NC_000017.11:g.7676590T>C	NM_000546.5:c.5A>G	no	no	G_G	A:T>G:C	A	G	0.106	GAG	GGG	Glu	Gly	0.106	missense	no		926778	0	no				NA	Transactivation TAD1	N-term/Transactivation	functional	notDNE_LOF	NA	NA	C0	Damaging	D	0.0978	0.481	2	84.4	57.3	96.9	84.9	90.1	75.6	132.5	117.7	E2G	7	560	4082	0	0	0	0.02	0	0.01	0	-522	29	-396	-69
7	7520633	7579908	7676590	2-exon	2	A>T	c.5A>T	g.7579908T>A	g.7676590T>A	p.E2V	NC_000017.10:g.7579908T>A	NC_000017.11:g.7676590T>A	NM_000546.5:c.5A>T	no	no	G_G	A:T>T:A	A	T	0.036	GAG	GTG	Glu	Val	0.036	missense	no			0	no				NA	Transactivation TAD1	N-term/Transactivation	supertrans	notDNE_notLOF	NA	NA	C0	Damaging	D	0.1191	0.485	2	134.4	150.6	146	108.2	89.2	97.7	163.9	176.8	E2V	8	563	4083	0	0	0	0	0	0	0	-522	29	-396	-69
8	7520632	7579907	7676589	2-exon	2	G>A	c.6G>A	g.7579907C>T	g.7676589C>T	p.E2E	NC_000017.10:g.7579907C>T	NC_000017.11:g.7676589C>T	NM_000546.5:c.6G>A	no	no	A_G	G:C>A:T	G	A	0.067	GAG	GAA	Glu	Glu	0.067	silent	no		183836	1	no	143458271	17-7579907-C-T	dbSNP150\|gnomAD\|flossies	NA	Transactivation TAD1	N-term/Transactivation	NA	notDNE_notLOF	NA	NA	NA	Tolerated	NA			0									E2E	9	559	4086	1	0	0	0	0.03	0	0	30	-186	-395	578
9	7520632	7579907	7676589	2-exon	2	G>C	c.6G>C	g.7579907C>G	g.7676589C>G	p.E2D	NC_000017.10:g.7579907C>G	NC_000017.11:g.7676589C>G	NM_000546.5:c.6G>C	no	no	A_G	G:C>C:G	G	C	0.022	GAG	GAC	Glu	Asp	0.03	missense	no			0	no				NA	Transactivation TAD1	N-term/Transactivation	functional	notDNE_notLOF	NA	NA	C0	Damaging	P	0.0779	0.582	2	110	77.1	105	74.3	72.1	70	135.4	144.6	E2D	11	558	4087	0	0	0	0	0.02	0	0	30	604	-395	578
10	7520632	7579907	7676589	2-exon	2	G>T	c.6G>T	g.7579907C>A	g.7676589C>A	p.E2D	NC_000017.10:g.7579907C>A	NC_000017.11:g.7676589C>A	NM_000546.5:c.6G>T	no	no	A_G	G:C>T:A	G	T	0.008	GAG	GAT	Glu	Asp	0.03	missense	no			0	no				NA	Transactivation TAD1	N-term/Transactivation	functional	notDNE_notLOF	NA	NA	C0	Damaging	P	0.0779	0.582	2	110	77.1	105	74.3	72.1	70	135.4	144.6	E2D	12	558	4088	0	0	0	0	0.02	0	0	30	151	-395	-68
11	7520631	7579906	7676588	2-exon	3	G>A	c.7G>A	g.7579906C>T	g.7676588C>T	p.E3K	NC_000017.10:g.7579906C>T	NC_000017.11:g.7676588C>T	NM_000546.5:c.7G>A	no	no	G_A	G:C>A:T	G	A	0.235	GAG	AAG	Glu	Lys	0.235	missense	no		858236	0	no				NA	Transactivation TAD1	N-term/Transactivation	functional	notDNE_notLOF	NA	NA	C0	Damaging	P	0.1957	0.575	2	132.1	143.5	174.8	90.3	82.8	85.5	138.1	170.3	E3K	9	633	4089	0	0	0	0	0.03	0	0	31	-185	-394	-985

View Data: Functional / Structural Data in TP53 with Annotations