TP53 Database: View Frequency of Individual Variants in Case-Controls Series

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	MUT_ID	hgvs_hg38	hgvs_NM_000546	ProtDescription	SNPlink	gnomADlink	COSMIClink	CLINVARlink	TCGA_ICGC_GENIE_count	Freq_cases	Freq_controls	Total_Cases	N_Cases	Total_Controls	N_Controls	DataSource	StudyDetails	AGVGDClass	SIFTClass	REVEL	BayesDel	TransactivationClass	DNE_LOFclass	DNEclass

	MUT_ID	hgvs_hg38	hgvs_NM_000546	ProtDescription	SNPlink	gnomADlink	COSMIClink	CLINVARlink	TCGA_ICGC_GENIE_count	Freq_cases	Freq_controls	Total_Cases	N_Cases	Total_Controls	N_Controls	DataSource	StudyDetails	AGVGDClass	SIFTClass	REVEL	BayesDel	TransactivationClass	DNE_LOFclass	DNEclass

	19	NC_000017.11:g.7676586C>A	NM_000546.5:c.9G>T	p.E3D					0	1.4E-4	9.0E-5	7051	1	11241	1	PMID:30287823	Cases: 7051 unselected women with breast cancer; Controls: 11241 unaffected women of Japanese ancestry	C0	Tolerated	0.523	0.0189	functional	notDNE_notLOF
	19	NC_000017.11:g.7676586C>A	NM_000546.5:c.9G>T	p.E3D					0	0.0	1.0E-4	53	0	12490	1	PMID:30287823	Cases: 53 unselected men with breast cancer; Controls: 12490 unaffected men of Japanese ancestry	C0	Tolerated	0.523	0.0189	functional	notDNE_notLOF
	73	NC_000017.11:g.7676568G>A	NM_000546.5:c.27C>T	p.S9S	757282628	17-7579886-G-A		215762	3	1.4E-4	2.7E-4	7051	1	11241	3	PMID:30287823	Cases: 7051 unselected women with breast cancer; Controls: 11241 unaffected women of Japanese ancestry		Tolerated				notDNE_notLOF
	73	NC_000017.11:g.7676568G>A	NM_000546.5:c.27C>T	p.S9S	757282628	17-7579886-G-A		215762	3	0.0	2.0E-4	53	0	12490	3	PMID:30287823	Cases: 53 unselected men with breast cancer; Controls: 12490 unaffected men of Japanese ancestry		Tolerated				notDNE_notLOF
	74	NC_000017.11:g.7676567C>T	NM_000546.5:c.28G>A	p.V10I	535274413	17-7579885-C-T	45361	127806	1	0.0	9.0E-5	7051	0	11241	1	PMID:30287823	Cases: 7051 unselected women with breast cancer; Controls: 11241 unaffected women of Japanese ancestry	C0	Tolerated	0.474	-0.0961	functional	notDNE_notLOF
	74	NC_000017.11:g.7676567C>T	NM_000546.5:c.28G>A	p.V10I	535274413	17-7579885-C-T	45361	127806	1	0.0	2.0E-4	53	0	12490	2	PMID:30287823	Cases: 53 unselected men with breast cancer; Controls: 12490 unaffected men of Japanese ancestry	C0	Tolerated	0.474	-0.0961	functional	notDNE_notLOF
	84	NC_000017.11:g.7676564C>G	NM_000546.5:c.31G>C	p.E11Q	201382018	17-7579882-C-G	11606	41723	2	0.01	0.01	7051	96	11241	172	PMID:30287823	Cases: 7051 unselected women with breast cancer; Controls: 11241 unaffected women of Japanese ancestry	C0	Damaging	0.449	0.089	functional	notDNE_notLOF
	84	NC_000017.11:g.7676564C>G	NM_000546.5:c.31G>C	p.E11Q	201382018	17-7579882-C-G	11606	41723	2	0.01	0.01	53	1	12490	185	PMID:30287823	Cases: 53 unselected men with breast cancer; Controls: 12490 unaffected men of Japanese ancestry	C0	Damaging	0.449	0.089	functional	notDNE_notLOF
	271	NC_000017.11:g.7676388G>A	NM_000546.5:c.90C>T	p.N30N	370992294	17-7579706-G-A		215764	0	0.0	9.0E-5	7051	0	11241	1	PMID:30287823	Cases: 7051 unselected women with breast cancer; Controls: 11241 unaffected women of Japanese ancestry		Tolerated				notDNE_notLOF
	272	NC_000017.11:g.7676387C>T	NM_000546.5:c.91G>A	p.V31I	201753350	17-7579705-C-T	45360	127827	0	0.01	0.01	7051	94	11241	139	PMID:30287823	Cases: 7051 unselected women with breast cancer; Controls: 11241 unaffected women of Japanese ancestry	C0	Tolerated	0.569	-0.0168	functional	notDNE_notLOF

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