TP53 Database: View <em>TP53</em> Variant Status of Human Cell-lines

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	Sample_ID	Sample_Name	ATCC_ID	Cosmic_ID	Short_topo	Morphology	Tumor_origin	Add_info	Sex	Age	Country	Population	Germline_mutation	Infectious_agent	Tobacco	Alcohol	Exposure	KRAS_status	Other_mutations	TP53status	p53_IHC	TP53_LOH	MUT_ID	hg18_Chr17_coordinates	hg19_Chr17_coordinates	hg38_Chr17_coordinates	ExonIntron	Codon_number	Description	Type	c_description	g_description	g_description_GRCh38	WT_nucleotide	Mutant_nucleotide	WT_codon	Mutant_codon	WT_AA	Mutant_AA	Effect	ProtDescription	COSMIClink	TCGA_ICGC_GENIE_count	Hotspot	AGVGDClass	SIFTClass	Polyphen2	REVEL	BayesDel	StructureFunctionClass	TransactivationClass	DNEclass	DNE_LOFclass	WAF1nWT	MDM2nWT	BAXnWT	AIP1nWT	h1433snWT	GADD45nWT	NOXAnWT	P53R2nWT	Ref_ID	Journal	Year	Volume	Start_page	PubMed	Start_material	Prescreening	Material_sequenced	exon2	exon3	exon4	exon5	exon6	exon7	exon8	exon9	exon10	exon11

	Sample_ID	Sample_Name	ATCC_ID	Cosmic_ID	Short_topo	Morphology	Tumor_origin	Add_info	Sex	Age	Country	Population	Germline_mutation	Infectious_agent	Tobacco	Alcohol	Exposure	KRAS_status	Other_mutations	TP53status	p53_IHC	TP53_LOH	MUT_ID	hg18_Chr17_coordinates	hg19_Chr17_coordinates	hg38_Chr17_coordinates	ExonIntron	Codon_number	Description	Type	c_description	g_description	g_description_GRCh38	WT_nucleotide	Mutant_nucleotide	WT_codon	Mutant_codon	WT_AA	Mutant_AA	Effect	ProtDescription	COSMIClink	TCGA_ICGC_GENIE_count	Hotspot	AGVGDClass	SIFTClass	Polyphen2	REVEL	BayesDel	StructureFunctionClass	TransactivationClass	DNEclass	DNE_LOFclass	WAF1nWT	MDM2nWT	BAXnWT	AIP1nWT	h1433snWT	GADD45nWT	NOXAnWT	P53R2nWT	Ref_ID	Journal	Year	Volume	Start_page	PubMed	Start_material	Prescreening	Material_sequenced	exon2	exon3	exon4	exon5	exon6	exon7	exon8	exon9	exon10	exon11

	3	BT-20	HTB-19	906801	BREAST	Carcinoma, NOS	primary		F	74	NA	NA	NA	NA	NA	NA	NA	NA	NA	MUT	positive	NA	1407	7519261	7578536	7675218	5-exon	132	A>C	A:T>C:G	c.394A>C	g.7578536T>G	g.7675218T>G	A	C	AAG	CAG	Lys	Gln	missense	p.K132Q	11224	9	yes	C45	Damaging	D	0.944	0.5995	non-functional	non-functional	NA	DNE_LOF	17.9	24.1	11.6	6.1	7.9	3.1	5.7	6.2	2	Oncogene	1990	5	893	0001694291	RNA	none	direct	true	true	true	true	true	true	true	true	true	true
	4	BT-474	HTB-20	946359	BREAST	Infiltrating duct carcinoma, NOS (C50._)	primary		F	60	NA	NA	NA	NA	NA	NA	NA	NA	NA	MUT	positive	NA	3932	7517810	7577085	7673767	8-exon	285	G>A	G:C>A:T	c.853G>A	g.7577085C>T	g.7673767C>T	G	A	GAG	AAG	Glu	Lys	missense	p.E285K	10722	160	yes	C55	Damaging	D	0.91	0.4445	non-functional	non-functional	Moderate	DNE_LOF	0.9	1.9	7.4	4.0	3.5	5.2	4.7	4.9	2	Oncogene	1990	5	893	0001694291	RNA	none	direct	true	true	true	true	true	true	true	true	true	true
	5	BT-549	HTB-122	905951	BREAST	Infiltrating duct carcinoma, NOS (C50._)	primary		F	72	NA	NA	NA	NA	NA	NA	NA	NA	RB1	MUT	positive	NA	3326	7518259	7577534	7674216	7-exon	249	G>C	G:C>C:G	c.747G>C	g.7577534C>G	g.7674216C>G	G	C	AGG	AGC	Arg	Ser	missense	p.R249S	10785	17	yes	C65	Damaging	D	0.769	0.4313	non-functional	non-functional	Yes	DNE_LOF	20.5	26.2	17.0	6.2	6.4	4.8	8.7	11.5	2	Oncogene	1990	5	893	0001694291	RNA	none	direct	true	true	true	true	true	true	true	true	true	true
	6	MDA-MB-231	HTB-26	905960	BREAST	Adenocarcinoma, NOS	primary		F	51	NA	NA	NA	NA	NA	NA	NA	NA	NA	MUT	positive	NA	3849	7517824	7577099	7673781	8-exon	280	G>A	G:C>A:T	c.839G>A	g.7577099C>T	g.7673781C>T	G	A	AGA	AAA	Arg	Lys	missense	p.R280K	10728	62	yes	C25	Damaging	D	0.935	0.5921	non-functional	non-functional	Yes	notDNE_LOF	0.8	0.5	1.7	0.0	0.0	0.9	0.0	1.0	2	Oncogene	1990	5	893	0001694291	RNA	none	direct	true	true	true	true	true	true	true	true	true	true
	18	DLD-1	CCL-221		COLON	Adenocarcinoma, NOS	NA		M		NA	NA	NA	NA	NA	NA	NA	KRAS MUT	MGMT	MUT	NA	Yes	3170	7518284	7577559	7674241	7-exon	241	C>T	G:C>A:T	c.722C>T	g.7577559G>A	g.7674241G>A	C	T	TCC	TTC	Ser	Phe	missense	p.S241F	10812	125	yes	C65	Damaging	D	0.958	0.545	non-functional	non-functional	Yes	DNE_LOF	0.0	0.0	0.3	0.0	0.0	0.0	0.0	0.8	5	Proc Natl Acad Sci U S A	1990	87	7555	0001699228	RNA	Mismatch cleavage		false	false	false	true	true	true	true	false	false	false
	20	SW620		905962	COLORECTUM, NOS	Carcinoma, NOS	NA		NA		NA	NA	NA	NA	NA	NA	NA	NA	NA	MUT	NA	Yes	3737	7517845	7577120	7673802	8-exon	273	G>A	G:C>A:T at CpG	c.818G>A	g.7577120C>T	g.7673802C>T	G	A	CGT	CAT	Arg	His	missense	p.R273H	10660	635	yes	C25	Damaging	D	0.868	0.5259	non-functional	non-functional	Yes	DNE_LOF	1.7	0.0	2.4	0.0	0.0	0.0	0.0	16.0	5	Proc Natl Acad Sci U S A	1990	87	7555	0001699228	RNA	Mismatch cleavage		false	false	false	true	true	true	true	false	false	false
	21	WiDr	CCL-218	909783	COLON	Adenocarcinoma, NOS	NA		F	78	NA	NA	NA	NA	NA	NA	NA	NA	NA	MUT	NA	Yes	3737	7517845	7577120	7673802	8-exon	273	G>A	G:C>A:T at CpG	c.818G>A	g.7577120C>T	g.7673802C>T	G	A	CGT	CAT	Arg	His	missense	p.R273H	10660	635	yes	C25	Damaging	D	0.868	0.5259	non-functional	non-functional	Yes	DNE_LOF	1.7	0.0	2.4	0.0	0.0	0.0	0.0	16.0	5	Proc Natl Acad Sci U S A	1990	87	7555	0001699228	RNA	Mismatch cleavage		false	false	false	true	true	true	true	false	false	false
	23	HT-29	HTB-38	905939	COLORECTUM, NOS	Adenocarcinoma, NOS	NA		F	44	NA	NA	NA	NA	NA	NA	NA	KRAS WT	NA	MUT	NA	Yes	3737	7517845	7577120	7673802	8-exon	273	G>A	G:C>A:T at CpG	c.818G>A	g.7577120C>T	g.7673802C>T	G	A	CGT	CAT	Arg	His	missense	p.R273H	10660	635	yes	C25	Damaging	D	0.868	0.5259	non-functional	non-functional	Yes	DNE_LOF	1.7	0.0	2.4	0.0	0.0	0.0	0.0	16.0	5	Proc Natl Acad Sci U S A	1990	87	7555	0001699228	RNA	Mismatch cleavage		false	false	false	true	true	true	true	false	false	false
	80	STA-ET-2.1			BONES (other)	Ewing sarcoma	primary	Added info from Kovar H, 1993	NA		France	Western Europe	NA	NA	NA	NA	NA	NA	NA	MUT	NA	NA	3800	7517833	7577108	7673790	8-exon	277	G>A	G:C>A:T	c.830G>A	g.7577108C>T	g.7673790C>T	G	A	TGT	TAT	Cys	Tyr	missense	p.C277Y	43737	8	yes	C65	Damaging	D	0.94	0.5762	non-functional	non-functional	Moderate	notDNE_LOF	1.1	0.0	0.4	0.0	0.0	0.5	0.0	0.8	6	Oncogene	1993	8	2213	0008336944	DNA	DGGE	direct	false	false	false	true	true	true	true	false	false	false
	93	H231			LUNG	Small cell carcinoma, NOS	NA		NA		USA	Northern America	NA	NA	NA	NA	NA	NA	NA	MUT	NA	No	1447	7519253	7578528	7675210	5-exon	134	T>A	A:T>T:A	c.402T>A	g.7578528A>T	g.7675210A>T	T	A	TTT	TTA	Phe	Leu	missense	p.F134L	45167	8	yes	C15	Damaging	D	0.942	0.386	non-functional	non-functional	NA	DNE_LOF	17.7	16.8	12.4	5.7	7.5	2.8	3.7	4.9	7	Nature	1989	342	705	0002531845	RNA	none	cloned	true	true	true	true	true	true	true	true	true	true

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