p53 Target Genes

• Census and evaluation of p53 target genes:
  This study identified 350 genes that are confirmed direct p53 targets (see below) based on a meta-analysis of 15 genome-wide datasets and over 300 single-gene studies. These genes have roles in several cellular functions including apoptosis, cell-cycle arrest, autophagy, metabolism, DNA repair, translational control, feedback mechanisms.
  This study also summarizes several other studies that collectively show that p53 is not a direct repressor of genes but can indirectly repress genes through activation of the p21-DREAM/RB pathway. Most repressed genes through this p53-p21-DREAM/RB pathway are cell-cycle genes.
• Whole-genome cartography of p53 response elements ranked on transactivation potential:
  This study provides a comprehensive annotation of canonical and non-canonical p53 REs in the human genome, ranked on predicted transactivation potential.
• Identification of a core TP53 transcriptional program with highly distributed tumor suppressive activity:
  This study shows that TP53 activates a genetically robust transcriptional program with highly distributed tumor suppressive functions acting in diverse cellular contexts.
• Multiplex enhancer-reporter assays uncover unsophisticated TP53 enhancer logic:
  This study shows that TP53 enhancers represent a class of unsophisticated cell-autonomous enhancers containing a single TP53 binding site.
• Revealing a human p53 universe:
  This study used a common analysis pipeline to perform a meta-analysis of 41 datasets from genome-wide ChIP-seq studies, providing a platform to characterize p53 binding throughout the human genome.

Census p53 target genes by Fischer (2017)

p53 responsive-elements